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Akari Therapeutics, Plc, an oncology company, develops antibody-drug conjugates (ADC) for cancer-killing toxins. Its lead payload is PH1 to disrupt the function of spliceosomes and to trigger an immune response that leads to additional cancer cell killing. The company's lead product candidate is AKTX-101, a preclinical stage trop2-targeting ADC that combines PH1 with the trop2 antibody to treat solid tumor cancer types, including lung, breast, bladder, head and neck, gastric, pancreatic, colon, prostate, and others. Its payloads include PH1 is a novel payload that is a spliceosome modulator designed to disrupt RNA splicing within cancer cells. The company also develops AKTX-102, a novel bispecific ADC that utilizes PH1 as its payload to treat various solid tumor cancers. Akari Therapeutics, Plc is headquartered in Tampa, Florida.
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Akari Therapeutics plc is a clinical-stage biopharmaceutical company developing complement and immune-modulating therapies, with lead candidate nomacopan, a dual inhibitor of complement C5 and leukotriene B4, intended for rare and severe inflammatory disorders. Major long-term growth drivers include successful clinical development and regulatory approvals in orphan indications, potential label expansion into additional complement-mediated diseases, and partnerships or commercialization outcomes. Investors may find exposure to a differentiated dual-mechanism candidate addressing unmet needs in high-cost rare disease markets attractive.
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| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -18.30M | -19.79M | -10.01M | -17.75M | -17.42M |
| Net income | -17.30M | -19.79M | -10.01M | -6.97M | -17.61M |
| Selling general administrative | 9.28M | 9.66M | 11.36M | 13.53M | 8.08M |
| Selling and marketing expenses | - | - | 11.34M | - | - |
| Gross profit | - | -0.01M | -0.00M | - | - |
| Reconciled depreciation | 0.00M | 0.01M | 0.00M | 0.00M | 0.00M |
| Ebit | - | -19.55M | -16.81M | -23.09M | -17.21M |
| Ebitda | -17.27M | -19.53M | -16.80M | -28.52M | -17.02M |
| Depreciation and amortization | - | 0.01M | 0.00M | -5.43M | 0.20M |
| Operating income | -17.27M | -21.64M | -16.81M | -23.09M | -17.21M |
| Other operating expenses | 17.27M | 21.64M | 16.81M | 23.09M | 17.21M |
| Interest expense | 0.95M | 0.24M | 0.00M | -5.34M | 0.21M |
| Tax provision | -1.00M | 0.00M | - | -2.47M | - |
| Interest income | 0.00M | 0.01M | 0.08M | 0.05M | 0.01M |
| Net interest income | -0.95M | -0.24M | 0.08M | 0.05M | 0.01M |
| Income tax expense | -1.00M | - | - | -10.78M | 0.18M |
| Total revenue | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 17.27M | 21.64M | 16.81M | 23.89M | 17.21M |
| Cost of revenue | - | 0.01M | 0.00M | - | - |
| Total other income expense net | -1.03M | 1.85M | 6.80M | 5.34M | -0.21M |
| Net income from continuing ops | -17.30M | -19.79M | -10.01M | -17.75M | -17.42M |
| Net income applicable to common shares | - | - | - | - | -17.42M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 47.89M | 50.56M | 4.36M | 13.83M | 11.65M |
| Intangible assets | 34.00M | 39.18M | 0.01M | 0.02M | 0.02M |
| Other current assets | 0.26M | 0.15M | 0.50M | 0.10M | 0.09M |
| Total liab | 19.56M | 28.33M | 4.58M | 12.04M | 6.09M |
| Total stockholder equity | 28.33M | 22.23M | -0.23M | 1.79M | 5.55M |
| Other current liab | 2.83M | 4.24M | 2.91M | 11.09M | 4.30M |
| Common stock | - | 5.32M | 1.32M | 0.74M | 0.48M |
| Capital stock | 0.00M | 5.32M | - | 0.74M | 0.48M |
| Retained earnings | -264.55M | -247.25M | -227.46M | -217.45M | -199.71M |
| Good will | 8.43M | 8.43M | - | - | - |
| Cash | 5.20M | 2.60M | 3.85M | 13.25M | 9.36M |
| Total current liabilities | 12.35M | 19.91M | 4.58M | 12.04M | 6.09M |
| Net debt | -4.45M | 0.66M | -3.85M | -13.25M | -9.36M |
| Short term debt | 0.75M | 3.26M | - | - | - |
| Short long term debt | 0.75M | 3.26M | - | - | - |
| Short long term debt total | 0.75M | 3.26M | - | - | - |
| Other stockholder equity | 293.66M | 264.90M | 174.75M | 219.27M | 205.32M |
| Total current assets | 5.46M | 2.95M | 4.34M | 13.81M | 11.63M |
| Net tangible assets | - | - | - | - | 5.53M |
| Net receivables | - | 0.20M | - | 2.95M | - |
| Inventory | - | - | - | -2.49M | - |
| Accounts payable | 8.77M | 12.41M | 1.67M | 0.95M | 1.79M |
| Accumulated other comprehensive income | -0.78M | -0.74M | 51.15M | -0.77M | -0.54M |
| Non currrent assets other | - | - | 0.01M | - | - |
| Non current assets total | 42.43M | 47.61M | 0.01M | 0.02M | 0.02M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | - | 0.38M | 0.00M | - | - |
| Change to liabilities | - | - | - | - | -0.24M |
| Total cashflows from investing activities | - | 0.38M | - | - | - |
| Net borrowings | 1.05M | -0.85M | 0.00M | - | - |
| Total cash from financing activities | 13.17M | 10.99M | 7.02M | 25.29M | 14.29M |
| Change to operating activities | - | - | - | - | -1.74M |
| Net income | -17.30M | -19.79M | -10.01M | -17.75M | -17.42M |
| Change in cash | 2.60M | -1.19M | -9.40M | 3.89M | -4.69M |
| Begin period cash flow | 2.66M | 3.85M | 13.25M | 9.36M | 14.06M |
| End period cash flow | 5.26M | 2.66M | 3.85M | 13.25M | 9.36M |
| Total cash from operating activities | -10.57M | -12.55M | -16.43M | -21.50M | -18.85M |
| Issuance of capital stock | 10.72M | 11.81M | 7.02M | 25.19M | 14.29M |
| Depreciation | 0.00M | 0.01M | 0.00M | 0.00M | 0.00M |
| Other cashflows from investing activities | - | 0.38M | - | - | - |
| Change to account receivables | - | - | - | 1.70M | - |
| Other cashflows from financing activities | 13.17M | 0.03M | 0.00M | 0.09M | - |
| Change to netincome | - | - | - | - | 0.56M |
| Capital expenditures | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Change in working capital | -0.40M | 6.54M | -0.87M | 0.82M | -1.98M |
| Stock based compensation | 2.89M | 2.25M | 1.15M | 0.74M | 0.31M |
| Other non cash items | 5.33M | -1.56M | -6.71M | -5.32M | 0.24M |
| Free cash flow | -10.57M | -12.55M | -16.43M | -21.50M | -18.85M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| AKTX Akari Therapeutics PLC |
0.03 0.41% |
7.40 | - | - | 478368.50 | 1.17 | 400346.36 | -0.06 |
| NVO Novo Nordisk A/S |
0.47 1.18% |
40.78 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
1.49 0.27% |
548.58 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
8.76 0.97% |
913.11 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Akari Therapeutics, Plc, an oncology company, develops antibody-drug conjugates (ADC) for cancer-killing toxins. Its lead payload is PH1 to disrupt the function of spliceosomes and to trigger an immune response that leads to additional cancer cell killing. The company's lead product candidate is AKTX-101, a preclinical stage trop2-targeting ADC that combines PH1 with the trop2 antibody to treat solid tumor cancer types, including lung, breast, bladder, head and neck, gastric, pancreatic, colon, prostate, and others. Its payloads include PH1 is a novel payload that is a spliceosome modulator designed to disrupt RNA splicing within cancer cells. The company also develops AKTX-102, a novel bispecific ADC that utilizes PH1 as its payload to treat various solid tumor cancers. Akari Therapeutics, Plc is headquartered in Tampa, Florida.
| Name | Title | Year Born |
|---|---|---|
| Dr. Ray Prudo-Chlebosz M.D. | Exec. Chairman | 1945 |
| Dr. Torsten Hombeck | Chief Financial Officer | 1970 |
| Ms. Rachelle Suzanne Jacques | Pres, CEO & Director | 1971 |
| Ms. Melissa Bradford-Klug | Chief Operating Officer | NA |
| Dr. Miles Nunn | Chief Scientific Officer | NA |
| Dr. John F. Neylan III, M.D. | Exec. VP & Chief Medical Officer | 1953 |
| Annie Mack | Financial Controller | NA |
| Ms. Rachelle Suzanne Jacques | President, CEO & Director | 1971 |
| Ms. Wendy F. DiCicco CPA | Interim Chief Financial Officer | 1967 |
| Ms. Melissa Bradford-Klug | Chief Operating Officer | 1970 |
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