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Akebia Therapeutics, Inc., a biopharmaceutical company, focuses on the development and commercialization of therapeutics for patients with kidney diseases. Its product portfolio includes Vafseo (vadadustat), an oral hypoxia-inducible factor prolyl hydroxylase, for the treatment of anemia due to chronic kidney disease (CKD) in dialysis-dependent (DD) and non-dialysis dependent (NDD) patients; and Auryxia, a ferric citrate that is used to control the serum phosphorus levels in adult patients with DD-CKD and the treatment of iron deficiency anemia in adult patients with NDD-CKD. The company is also developing AKB-9090, which is in Phase 2 clinical trial for treating cardiac surgery-related acute kidney injury and acute respiratory distress syndrome; and AKB-10108 for the treatment of retinopathy of prematurity in neonates. The company has license and collaboration agreements with Tanabe Pharma Corporation for the development and commercialization of Vafseo in Japan and other Asian countries; Vafseo License and Collaboration Agreements; CSL Vifor Agreements; Averoa License Agreement; License Agreement with Panion & BF Biotech, Inc.; Cyclerion Therapeutics License Agreement; and Q32 Asset Purchase Agreement. Akebia Therapeutics, Inc. was incorporated in 2007 and is headquartered in Cambridge, Massachusetts.
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Akebia Therapeutics is a biopharmaceutical company focused on treatments for anemia in chronic kidney disease, primarily developing vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor in collaboration with Otsuka Pharmaceutical. Long-term growth drivers include potential adoption of an oral alternative to injectable erythropoiesis-stimulating agents, an expanding CKD patient population, and commercialization support from a global partner, which may benefit revenue scale if regulatory approvals and market uptake progress.
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| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -3.72M | -69.41M | -51.92M | -92.56M | -282.84M |
| Net income | -5.34M | -69.41M | -51.92M | -106.01M | -244.87M |
| Selling general administrative | 107.48M | 101.94M | 3.24M | 141.87M | 177.65M |
| Selling and marketing expenses | - | 4.60M | 100.23M | -3.17M | 174.16M |
| Gross profit | 196.73M | 97.00M | 120.47M | 207.81M | 60.18M |
| Reconciled depreciation | 1.27M | 37.50M | 37.64M | 37.70M | 37.97M |
| Ebit | 20.46M | -51.23M | -45.89M | -63.18M | -303.29M |
| Ebitda | 21.73M | -13.72M | -8.27M | -46.34M | -265.32M |
| Depreciation and amortization | 1.27M | 37.50M | 37.63M | 16.84M | 37.97M |
| Non operating income net other | - | - | - | 2.24M | 2.41M |
| Operating income | 23.50M | -50.47M | -46.26M | -63.18M | -265.32M |
| Other operating expenses | 212.70M | 210.65M | 240.88M | 355.78M | 478.90M |
| Interest expense | 24.18M | 18.18M | 6.03M | 15.69M | -19.94M |
| Tax provision | 1.62M | 0.00M | 0.00M | 0.00M | 0.00M |
| Net interest income | -24.18M | -18.18M | -6.25M | -15.69M | -19.94M |
| Non recurring | - | - | - | 15.93M | - |
| Income tax expense | 1.62M | - | 41.68M | 13.45M | -37.97M |
| Total revenue | 236.20M | 160.18M | 194.62M | 292.60M | 213.58M |
| Total operating expenses | 173.24M | 147.47M | 166.73M | 270.99M | 325.50M |
| Cost of revenue | 39.46M | 63.18M | 74.15M | 84.80M | 153.39M |
| Total other income expense net | -27.22M | -18.94M | -5.67M | -29.38M | -17.52M |
| Net income from continuing ops | -5.34M | -69.41M | -56.95M | -92.56M | -282.84M |
| Net income applicable to common shares | - | - | - | -92.56M | -282.84M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 376.56M | 220.67M | 241.70M | 351.83M | 525.55M |
| Intangible assets | - | - | 36.04M | 72.08M | 108.13M |
| Other current assets | -62.64M | 11.35M | 20.24M | 33.54M | 33.14M |
| Total liab | 343.95M | 269.86M | 272.29M | 342.49M | 449.09M |
| Total stockholder equity | 32.61M | -49.19M | -30.58M | 9.34M | 76.46M |
| Other current liab | 101.67M | 56.02M | 38.26M | 66.25M | 99.65M |
| Common stock | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Capital stock | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Retained earnings | -1683.70M | -1678.36M | -1608.95M | -1552.91M | -1460.35M |
| Other liab | - | - | - | 158.25M | 158.90M |
| Good will | 59.04M | 59.04M | 59.04M | 55.05M | 55.05M |
| Other assets | - | - | - | 94.48M | 640.27M |
| Cash | 184.84M | 51.87M | 42.92M | 90.47M | 149.80M |
| Total current liabilities | 162.94M | 80.91M | 99.87M | 124.76M | 256.49M |
| Current deferred revenue | - | 15.73M | 22.94M | 3.74M | 20.91M |
| Net debt | 31.45M | 136.86M | 61.26M | 9.32M | -13.75M |
| Short term debt | 40.08M | 9.71M | 24.04M | 36.74M | 102.34M |
| Short long term debt | - | - | 17.50M | 32.00M | 97.54M |
| Short long term debt total | 216.30M | 188.73M | 104.18M | 99.78M | 136.05M |
| Other stockholder equity | 1716.31M | 1629.17M | 1578.36M | 1562.25M | 1536.80M |
| Property plant equipment | - | - | - | 5.21M | 6.75M |
| Total current assets | 184.84M | 113.83M | 118.15M | 184.95M | 272.01M |
| Net tangible assets | - | - | - | -117.80M | -86.72M |
| Short term investments | - | - | - | - | 0.00M |
| Net receivables | 47.03M | 34.37M | 39.29M | 39.18M | 50.88M |
| Long term debt | 48.25M | 38.69M | 17.18M | 34.08M | 1.82M |
| Inventory | 15.61M | 16.24M | 15.69M | 21.76M | 38.20M |
| Accounts payable | 21.18M | 15.18M | 14.63M | 18.02M | 33.59M |
| Accumulated other comprehensive income | 0.01M | 0.01M | 0.01M | 0.01M | 0.01M |
| Common stock total equity | - | - | - | 0.00M | 0.00M |
| Retained earnings total equity | - | - | - | -1552.91M | -1460.35M |
| Non currrent assets other | 132.68M | 37.38M | 10.77M | 5.37M | 49.75M |
| Non current assets total | 191.72M | 106.84M | 123.55M | 166.88M | 253.54M |
| Capital lease obligations | 3.55M | 8.95M | 13.44M | 33.70M | 38.51M |
| Long term debt total | - | - | - | - | 1.82M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | - | -0.03M | 0.00M | -0.11M | 40.00M |
| Change to liabilities | - | - | - | -34.65M | -48.90M |
| Total cashflows from investing activities | -7.93M | -0.03M | - | -0.11M | 39.94M |
| Net borrowings | 9.54M | 7.90M | -32.00M | -33.00M | -33.00M |
| Total cash from financing activities | 72.93M | 49.66M | -25.21M | 14.60M | 133.73M |
| Change to operating activities | - | - | - | -37.98M | -48.63M |
| Net income | -5.34M | -69.41M | -51.92M | -92.56M | -282.84M |
| Change in cash | 132.99M | 8.97M | -48.59M | -58.67M | -79.29M |
| Begin period cash flow | 53.55M | 44.58M | 93.17M | 151.84M | 231.13M |
| End period cash flow | 186.54M | 53.55M | 44.58M | 93.17M | 151.84M |
| Total cash from operating activities | 67.99M | -40.66M | -23.38M | -73.15M | -252.97M |
| Issuance of capital stock | 66.68M | 42.65M | -0.00M | 7.12M | 88.20M |
| Depreciation | 1.27M | 37.50M | 41.85M | 37.70M | 37.97M |
| Other cashflows from investing activities | -7.93M | - | - | - | - |
| Change to inventory | -23.12M | -28.40M | -2.54M | 19.79M | -25.85M |
| Change to account receivables | -14.14M | 4.05M | 0.99M | 11.70M | -24.02M |
| Sale purchase of stock | - | -1.27M | 0.00M | 7.60M | 88.95M |
| Other cashflows from financing activities | -0.06M | 0.39M | 0.00M | 40.48M | 45.53M |
| Change to netincome | - | - | - | 46.73M | 37.08M |
| Capital expenditures | 0.29M | 0.03M | 0.00M | 0.11M | 0.06M |
| Change receivables | - | - | - | 11.70M | -24.02M |
| Cash flows other operating | - | - | - | -61.87M | 53.61M |
| Cash and cash equivalents changes | - | - | - | -58.67M | -79.29M |
| Change in working capital | 16.47M | -39.68M | -20.73M | -1.44M | -108.42M |
| Stock based compensation | 11.28M | 7.78M | 9.32M | 17.85M | 22.73M |
| Other non cash items | 44.31M | 23.15M | -1.90M | -34.70M | 41.01M |
| Free cash flow | 67.99M | -40.69M | -23.38M | -73.27M | -253.02M |
Sector: Healthcare Industry: Drug Manufacturers - Specialty & Generic
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| AKBA Akebia Ther |
-0.02 5.43% |
0.40 | - | 35.71 | 1.60 | 11.75 | 1.06 | 11.51 |
| MKKGY Merck KGaA ADR |
-0.22 0.66% |
33.17 | 21.25 | 14.93 | 3.10 | 2.14 | 3.60 | 12.98 |
| MKGAF MERCK Kommanditgesellschaft auf Aktien |
-2.76 1.62% |
167.12 | 24.86 | 15.11 | 3.13 | 1.98 | 3.08 | 18.89 |
| TAK Takeda Pharmaceutical Co Ltd ADR |
-0.17 0.80% |
21.02 | - | 10.96 | 0.01 | 1.20 | 2.94 | 23.11 |
| TKPHF Takeda Pharmaceutical Co. Ltd. |
- -% |
41.85 | - | 10.66 | 0.01 | 1.16 | 2.94 | 23.11 |
Akebia Therapeutics, Inc., a biopharmaceutical company, focuses on the development and commercialization of therapeutics for patients with kidney diseases. Its product portfolio includes Vafseo (vadadustat), an oral hypoxia-inducible factor prolyl hydroxylase, for the treatment of anemia due to chronic kidney disease (CKD) in dialysis-dependent (DD) and non-dialysis dependent (NDD) patients; and Auryxia, a ferric citrate that is used to control the serum phosphorus levels in adult patients with DD-CKD and the treatment of iron deficiency anemia in adult patients with NDD-CKD. The company is also developing AKB-9090, which is in Phase 2 clinical trial for treating cardiac surgery-related acute kidney injury and acute respiratory distress syndrome; and AKB-10108 for the treatment of retinopathy of prematurity in neonates. The company has license and collaboration agreements with Tanabe Pharma Corporation for the development and commercialization of Vafseo in Japan and other Asian countries; Vafseo License and Collaboration Agreements; CSL Vifor Agreements; Averoa License Agreement; License Agreement with Panion & BF Biotech, Inc.; Cyclerion Therapeutics License Agreement; and Q32 Asset Purchase Agreement. Akebia Therapeutics, Inc. was incorporated in 2007 and is headquartered in Cambridge, Massachusetts.
| Name | Title | Year Born |
|---|---|---|
| Mr. John P. Butler MBA | CEO, Pres & Director | 1964 |
| Mr. David A. Spellman | Sr. VP, CFO & Treasurer | 1977 |
| Mr. Michel Dahan | Sr. VP & COO | 1979 |
| Dr. Steven Keith Burke | Sr. VP of R&D and Chief Medical Officer | 1961 |
| Ms. Violetta Cotreau | Sr. VP, Chief Accounting Officer & Principal Accounting Officer | 1973 |
| Ms. Nicole R. Hadas | Sr. VP, Chief Legal Officer & Sec. | 1973 |
| Mercedes Carrasco | Director of Corp. Communications | NA |
| Mr. Douglas Jermasek M.B.A. | VP of Marketing & Strategy | NA |
| Ms. Meredith Bowman | Sr. VP of People | NA |
| Dr. Thierry Bilbault Ph.D. | Sr. VP of Manufacturing & Pharmaceutical Devel. | 1959 |
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