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Dyadic International, Inc., together with its subsidiaries, a biotechnology platform company, develops, manufactures, and commercializes proteins and enzymes in the United States. The company offers Dapibus Protein Production Platform, a proprietary expression system designed to produce non-animal proteins and enzymes for non-pharmaceutical markets, including life sciences, food and nutrition, and bio-industrial sector; and C1 Protein Production Platform, a thermophilic fungal platform for large-scale production of proteins. It has a research and development agreement with VTT Technical Research Centre of Finland, Ltd; license agreement with Rubic One Health to develop various livestock vaccines; sub-license agreement with Phibro Animal Health/Abic Biological Laboratories to develop vaccines and treatments for livestock diseases; and collaboration with Scripps Research to evaluate monoclonal antibody and vaccine candidates targeting hantaviruses. Dyadic International, Inc. was founded in 1979 and is headquartered in Jupiter, Florida.
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Dyadic International develops and licenses a proprietary C1 fungal-based protein expression platform used to produce enzymes and biologics for pharmaceutical, industrial and research customers. Long-term growth may benefit from wider adoption of the C1 platform, more licensing and service agreements, and regulatory acceptance; investors may find the company attractive for its technology focus and potential recurring partner revenue.
Investors should monitor limited commercial traction, competition from established expression systems, manufacturing and scale-up risks, regulatory hurdles for platform-derived biologics, and potential need for additional financing.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -7.36M | -5.81M | -6.80M | -9.74M | -13.07M |
| Net income | -7.36M | -5.81M | -6.80M | -9.37M | -12.92M |
| Selling general administrative | 5.76M | 6.13M | 5.82M | 6.42M | 6.70M |
| Gross profit | 0.77M | 2.30M | 0.92M | 0.81M | 0.46M |
| Ebit | - | -11.26M | -8.19M | -10.12M | -14.73M |
| Ebitda | -7.15M | -5.38M | -8.15M | -10.07M | -16.14M |
| Depreciation and amortization | - | 5.88M | 0.04M | 0.05M | -1.41M |
| Operating income | -7.15M | -5.90M | -8.23M | -10.12M | -14.73M |
| Other operating expenses | 10.28M | 9.40M | 11.13M | 13.05M | 17.03M |
| Interest expense | 0.46M | 0.43M | 0.00M | -0.38M | 0.05M |
| Tax provision | - | - | - | - | 0.00M |
| Interest income | 0.28M | 0.46M | 0.42M | 0.18M | 0.05M |
| Net interest income | -0.17M | 0.03M | 0.42M | 0.18M | 0.05M |
| Income tax expense | - | -5.81M | -8.19M | -0.36M | -0.15M |
| Total revenue | 3.09M | 3.50M | 2.90M | 2.93M | 2.40M |
| Total operating expenses | 7.92M | 8.20M | 9.15M | 10.92M | 15.09M |
| Cost of revenue | 2.32M | 1.19M | 1.98M | 2.12M | 1.94M |
| Total other income expense net | -0.22M | 0.09M | 1.43M | 0.38M | 1.66M |
| Net income from continuing ops | -7.36M | -5.81M | -6.80M | -9.74M | -13.07M |
| Net income applicable to common shares | - | - | - | -9.74M | -13.07M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 9.95M | 9.93M | 8.22M | 13.71M | 21.30M |
| Other current assets | 1.45M | 0.33M | 0.33M | 0.39M | 0.38M |
| Total liab | 8.71M | 7.46M | 2.34M | 2.63M | 2.91M |
| Total stockholder equity | 1.23M | 2.47M | 5.88M | 11.09M | 18.39M |
| Other current liab | 2.80M | 1.91M | 1.14M | 1.00M | 0.86M |
| Common stock | 0.05M | 0.04M | 0.04M | 0.04M | 0.04M |
| Capital stock | 0.05M | 0.04M | 0.04M | 0.04M | 0.04M |
| Retained earnings | -93.45M | -86.09M | -80.28M | -73.48M | -63.75M |
| Other liab | - | - | - | 0.18M | 0.35M |
| Other assets | - | - | - | 0.01M | 0.01M |
| Cash | 4.62M | 6.51M | 6.52M | 5.79M | 15.75M |
| Total current liabilities | 3.69M | 2.45M | 2.25M | 2.45M | 2.56M |
| Current deferred revenue | - | - | 0.49M | 0.18M | 0.15M |
| Net debt | 0.44M | -1.44M | -6.38M | -5.79M | -15.75M |
| Short term debt | 0.03M | 0.05M | 0.05M | - | - |
| Short long term debt total | 5.06M | 5.07M | 0.14M | - | - |
| Other stockholder equity | 94.64M | 88.51M | 86.11M | 84.53M | 82.10M |
| Total current assets | 9.90M | 9.83M | 8.07M | 13.42M | 21.01M |
| Long term investments | - | - | 0.00M | 0.28M | 0.28M |
| Net tangible assets | - | - | - | 11.09M | 18.39M |
| Short term investments | 2.70M | 2.76M | 0.75M | 6.85M | 4.51M |
| Net receivables | 1.13M | 0.24M | 0.48M | 0.39M | 0.37M |
| Long term debt | 5.03M | 4.98M | - | - | - |
| Inventory | - | - | 0.00M | - | - |
| Accounts payable | 0.85M | 0.48M | 0.58M | 1.28M | 1.55M |
| Accumulated other comprehensive income | - | 0.00M | 0.00M | - | - |
| Non currrent assets other | 0.01M | 0.01M | 0.01M | 0.01M | 0.01M |
| Non current assets total | 0.05M | 0.10M | 0.15M | 0.29M | 0.29M |
| Capital lease obligations | 0.03M | 0.09M | 0.14M | - | - |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | 0.08M | -1.88M | 7.45M | -2.37M | 5.22M |
| Change to liabilities | - | - | - | -0.51M | 1.08M |
| Total cashflows from investing activities | 0.08M | -1.88M | 7.45M | -2.37M | 5.22M |
| Net borrowings | 0.00M | 5.82M | 0.00M | - | - |
| Total cash from financing activities | 4.96M | 5.85M | 0.00M | 0.54M | 1.23M |
| Change to operating activities | - | - | - | 0.27M | 0.14M |
| Net income | -7.36M | -5.81M | -6.80M | -9.74M | -13.07M |
| Change in cash | -0.65M | -0.01M | 0.72M | -9.95M | -4.89M |
| Begin period cash flow | 6.51M | 6.52M | 5.79M | 15.75M | 20.64M |
| End period cash flow | 5.85M | 6.51M | 6.52M | 5.79M | 15.75M |
| Total cash from operating activities | -5.70M | -3.97M | -6.73M | -8.08M | -11.28M |
| Issuance of capital stock | 4.94M | 0.00M | - | - | - |
| Depreciation | -0.02M | -0.07M | -0.05M | 0.03M | 0.33M |
| Change to inventory | - | - | - | - | 0.14M |
| Change to account receivables | -0.86M | 0.21M | -0.09M | -0.08M | -0.03M |
| Other cashflows from financing activities | 4.96M | 0.02M | 7.45M | 0.54M | 1.23M |
| Change to netincome | - | - | - | 1.97M | 0.61M |
| Capital expenditures | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Change in working capital | 0.66M | 0.75M | -0.14M | -0.32M | 1.19M |
| Stock based compensation | 0.93M | 1.13M | 1.24M | 1.89M | 1.78M |
| Other non cash items | 0.10M | -0.05M | -1.03M | 0.05M | -1.18M |
| Free cash flow | -5.70M | -3.97M | -6.73M | -8.08M | -11.28M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| DYAI Dyadic International Inc |
-0.00 0.09% |
0.34 | - | 15.82 | 4.51 | 21.01 | 14.20 | -2.93 |
| NVO Novo Nordisk A/S |
0.01 0.02% |
40.31 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
4.59 0.85% |
547.09 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
1.45 0.16% |
904.35 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Dyadic International, Inc., together with its subsidiaries, a biotechnology platform company, develops, manufactures, and commercializes proteins and enzymes in the United States. The company offers Dapibus Protein Production Platform, a proprietary expression system designed to produce non-animal proteins and enzymes for non-pharmaceutical markets, including life sciences, food and nutrition, and bio-industrial sector; and C1 Protein Production Platform, a thermophilic fungal platform for large-scale production of proteins. It has a research and development agreement with VTT Technical Research Centre of Finland, Ltd; license agreement with Rubic One Health to develop various livestock vaccines; sub-license agreement with Phibro Animal Health/Abic Biological Laboratories to develop vaccines and treatments for livestock diseases; and collaboration with Scripps Research to evaluate monoclonal antibody and vaccine candidates targeting hantaviruses. Dyadic International, Inc. was founded in 1979 and is headquartered in Jupiter, Florida.
1044 North U.S. Highway One, Jupiter, FL, United States, 33477-5094
561 743 8333
5
| Name | Title | Year Born |
|---|---|---|
| Mr. Mark A. Emalfarb | Founder, CEO, Pres & Director | 1956 |
| Ms. Ping Wang Rawson CPA, M.B.A. | Chief Financial Officer | 1976 |
| Mr. Joseph P. Hazelton | Chief Bus. Officer | NA |
| Dr. Ronen Tchelet Ph.D. | VP of Research & Bus. Devel. | 1958 |
| Ms. Ana Gómez Rodriguez | Sec. of the Board | NA |
| Mr. Mark A. Emalfarb | Founder, CEO, President & Director | 1956 |
| Mr. Joseph P. Hazelton | Chief Business Officer | NA |
| Mr. Doug Pace B.A. | Executive Vice President of Business Development | NA |
| Ms. Ana Gómez Rodriguez | Secretary of the Board | NA |
| Mr. Mark A. Emalfarb | Founder, CEO & Director | 1956 |
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