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eFFECTOR Therapeutics, Inc., a biopharmaceutical company, engages in the development of selective translation regulator inhibitors for the treatment of cancer. The company's lead product candidate includes Zotatifin, an inhibitor of eIF4A, which is in Phase 1/2 clinical trial to treat patients with solid tumors, as well as has completed Phase 2 clinical trial in combination with fulvestrant and abemaciclib to treat patients with ER+ breast cancer. It also develops Tomivosertib, an oral small-molecule inhibitor of MNK that is in phase 2b clinical trial for the treatment of patients with metastatic non-small cell lung cancer. It has a research collaboration and license agreement with Pfizer Inc. to research and develop small molecules that target eIF4E. eFFECTOR Therapeutics, Inc. was founded in 2012 and is headquartered in Solana Beach, California.
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Effector Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing small-molecule therapeutics and advancing R&D and clinical programs. Long-term growth drivers may include positive clinical data readouts, regulatory approvals, and licensing or partnership deals that could support pipeline commercialization and value creation.
Primary investment risks include clinical trial failure risk, the need for additional financing with potential dilution, regulatory uncertainty, and strong competition in the drug development sector.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
| Income before tax | -35.81M | -22.66M | 15.80M | 14.56M | - |
| Net income | -35.81M | -12.93M | 15.80M | 14.21M | - |
| Selling general administrative | 10.93M | 12.64M | 13.37M | 4.35M | - |
| Gross profit | -0.11M | - | 1.43M | 42.00M | - |
| Reconciled depreciation | 0.11M | 0.05M | 0.02M | 0.16M | - |
| Ebit | -32.89M | -32.46M | -31.92M | 15.82M | -28.61M |
| Ebitda | -32.78M | -32.40M | -31.90M | 16.05M | - |
| Depreciation and amortization | 0.11M | 0.05M | 0.02M | 0.24M | - |
| Non operating income net other | - | - | 49.46M | - | - |
| Operating income | -33.84M | -32.40M | -31.90M | 15.82M | - |
| Other operating expenses | 33.84M | 32.40M | 31.90M | 26.18M | - |
| Interest expense | 2.92M | 2.25M | 1.76M | 1.33M | 0.00M |
| Tax provision | - | - | 0.00M | 0.35M | - |
| Interest income | 0.96M | 0.44M | 0.01M | 0.07M | - |
| Net interest income | -1.90M | -1.81M | -1.76M | -1.27M | - |
| Income tax expense | - | -9.74M | -0.02M | 0.35M | - |
| Total revenue | 0.00M | 0.00M | 1.43M | 42.00M | - |
| Total operating expenses | 33.84M | 32.40M | 31.90M | 26.18M | - |
| Cost of revenue | 0.11M | - | - | - | - |
| Total other income expense net | -1.97M | 9.74M | 47.70M | -1.26M | - |
| Net income from continuing ops | -35.94M | -22.66M | 15.80M | 14.21M | - |
| Net income applicable to common shares | - | -22.66M | 15.80M | 0.17M | -14.21M |
| Breakdown | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
| Total assets | 20.54M | 29.08M | 54.06M | 16.70M | - |
| Other current assets | 1.42M | 1.70M | 3.19M | 1.36M | - |
| Total liab | 26.34M | 25.18M | 36.77M | 148.95M | - |
| Total stockholder equity | -5.79M | 3.90M | 17.28M | -132.25M | - |
| Other current liab | 4.02M | 3.37M | 3.42M | 0.43M | 0.44M |
| Common stock | - | 0.00M | 0.00M | 0.00M | 0.00M |
| Capital stock | 0.00M | 0.00M | 0.00M | 0.00M | - |
| Retained earnings | -179.38M | -143.57M | -120.90M | -136.70M | -150.91M |
| Other liab | - | 0.05M | 12.81M | - | - |
| Other assets | 0.00M | 0.71M | 0.90M | 0.18M | - |
| Cash | 14.88M | 8.71M | 49.70M | 15.22M | - |
| Total current liabilities | 25.80M | 25.07M | 3.98M | 8.78M | 18.93M |
| Current deferred revenue | - | - | - | 1.98M | - |
| Net debt | 4.57M | 11.57M | -29.67M | -2.25M | - |
| Short term debt | 19.45M | 20.22M | 0.04M | 6.01M | - |
| Short long term debt | 20.48M | 20.16M | - | 5.91M | - |
| Short long term debt total | 19.45M | 20.28M | 20.03M | 12.96M | - |
| Other stockholder equity | 173.58M | 147.48M | 138.18M | 4.45M | - |
| Property plant equipment | - | 0.35M | 0.09M | 0.13M | 0.82M |
| Total current assets | 19.84M | 28.01M | 52.90M | 16.58M | 4.27M |
| Net tangible assets | - | 3.90M | 17.28M | -132.25M | -147.06M |
| Short term investments | 3.50M | 17.60M | - | - | - |
| Net receivables | 0.05M | 0.03M | 0.10M | - | - |
| Long term debt | - | - | 19.86M | 6.95M | - |
| Accounts payable | 2.33M | 1.49M | 0.52M | 0.35M | 0.60M |
| Accumulated other comprehensive income | 0.00M | -0.02M | -54.06M | - | - |
| Common stock total equity | - | - | 0.00M | 0.00M | - |
| Retained earnings total equity | - | - | -120.90M | - | - |
| Non currrent assets other | 0.51M | 0.71M | 0.90M | - | - |
| Non current assets total | 0.71M | 1.06M | 1.16M | 0.13M | - |
| Capital lease obligations | 0.06M | 0.12M | 0.17M | 0.11M | - |
| Breakdown | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
| Investments | 9.16M | -17.86M | 0.56M | -0.15M | -17.67M |
| Change to liabilities | - | 0.96M | 1.95M | -0.25M | -0.73M |
| Total cashflows from investing activities | 14.48M | -17.86M | 0.56M | -0.15M | 0.08M |
| Net borrowings | - | - | 19.84M | -2.00M | -2.00M |
| Total cash from financing activities | 21.23M | 2.77M | 58.81M | -1.89M | 20.24M |
| Change to operating activities | - | 1.72M | -0.39M | -0.57M | 1.80M |
| Net income | -35.81M | -22.66M | 15.80M | 14.21M | -14.21M |
| Change in cash | 6.17M | -40.99M | 34.49M | 11.79M | -7.27M |
| Begin period cash flow | 8.71M | 49.70M | 15.22M | 3.43M | - |
| End period cash flow | 14.88M | 8.71M | 49.70M | 15.22M | 3.43M |
| Total cash from operating activities | -29.55M | -25.90M | -24.89M | 13.84M | -27.60M |
| Issuance of capital stock | 15.03M | 2.80M | - | - | - |
| Depreciation | 0.11M | 0.05M | 0.02M | 0.16M | 0.31M |
| Other cashflows from investing activities | - | - | 0.56M | - | - |
| Sale purchase of stock | - | - | 0.06M | - | - |
| Other cashflows from financing activities | 0.06M | -0.03M | 72.75M | 0.11M | -0.09M |
| Change to netincome | - | -5.96M | 8.44M | 14.33M | -14.77M |
| Capital expenditures | 0.10M | 0.19M | 0.04M | 0.15M | 0.00M |
| Cash flows other operating | - | - | -51.09M | - | - |
| Cash and cash equivalents changes | - | - | 34.49M | - | - |
| Change in working capital | 1.69M | 2.68M | -0.24M | -0.82M | - |
| Stock based compensation | 4.59M | 5.33M | 8.66M | 0.50M | - |
| Other non cash items | -0.13M | -11.30M | -48.59M | 0.12M | - |
| Free cash flow | -29.65M | -26.09M | -24.93M | 13.68M | - |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|
| EFTR Effector Therapeutics Inc |
- -% |
0.00 | - | - | 69.65 | 0.00 | -0.41 |
| NVO Novo Nordisk A/S |
0.01 0.02% |
40.31 | 41.58 | 31.15 | 2.13 | 32.99 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
4.59 0.85% |
547.09 | 30.22 | 24.27 | 10.36 | 6.50 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
1.45 0.16% |
904.35 | 29.07 | 20.12 | 7.57 | 3.82 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 36.06 |
eFFECTOR Therapeutics, Inc., a biopharmaceutical company, engages in the development of selective translation regulator inhibitors for the treatment of cancer. The company's lead product candidate includes Zotatifin, an inhibitor of eIF4A, which is in Phase 1/2 clinical trial to treat patients with solid tumors, as well as has completed Phase 2 clinical trial in combination with fulvestrant and abemaciclib to treat patients with ER+ breast cancer. It also develops Tomivosertib, an oral small-molecule inhibitor of MNK that is in phase 2b clinical trial for the treatment of patients with metastatic non-small cell lung cancer. It has a research collaboration and license agreement with Pfizer Inc. to research and develop small molecules that target eIF4E. eFFECTOR Therapeutics, Inc. was founded in 2012 and is headquartered in Solana Beach, California.
142 North Cedros Avenue, Solana Beach, CA, United States, 92075
858 925 8215
14
| Name | Title | Year Born |
|---|---|---|
| Dr. Stephen T. Worland Ph.D. | CEO, Pres & Director | 1958 |
| Mr. Michael Byrnes M.B.A. | Chief Financial Officer | 1977 |
| Dr. Siegfried Reich Ph.D. | Co-Founder and Member of Clinical & Scientific Advisory Board | 1960 |
| Dr. Davide Ruggero Ph.D. | Co-Founder and Member of Clinical & Scientific Advisory Board | NA |
| Dr. Kevan M. Shokat Ph.D. | Co-Founder and Member of Clinical & Scientific Advisory Board | NA |
| Dr. Douglas Warner M.D. | Chief Medical Officer | NA |
| Dr. Mayank J. Gandhi M.D. | Chief Bus. Officer | 1978 |
| Dr. Stephen T. Worland Ph.D. | CEO, President & Director | 1958 |
| Dr. Douglas Warner M.D. | Chief Medical Officer | 1972 |
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