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Evelo Biosciences, Inc., a clinical-stage biotechnology company, focuses on discovering and developing oral medicines that act on immune cells in the small intestine with systemic effects. It is developing EDP1815, a whole-microbe product candidate, which has completed a Phase 2 trial for the treatment of psoriasis . The company is also developing EDP1867, a non-live pharmaceutical preparation for single strain of Veillonella parvula, which is in Phase 1b clinical trial; EDP2939, an investigational oral biologic for the potential treatment of inflammatory diseases; and EDP1908, a product candidate for oncology. Evelo Biosciences, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts.
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A unique technical analysis driven score developed by Kalkine showing momentum in stock prices based on select technical indicators identified.
Evelo Biosciences is a clinical-stage biotechnology company developing orally delivered biologic therapies intended to modulate the gut-immune axis for inflammatory and immuno-oncology indications. Long-term growth may be driven by positive clinical trial readouts, regulatory approvals, scalable manufacturing and commercial partnerships, and increasing scientific interest in microbiome-linked approaches, which could support future revenue if programs reach the market.
Material risks include high clinical and regulatory uncertainty, ongoing negative cash flow and fundraising needs, the potential for program failures, and limited liquidity and disclosure typical of small PINK-listed biotech stocks.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
| Income before tax | -81.44M | -113.60M | -121.75M | -93.26M | -85.47M |
| Net income | -82.35M | -114.53M | -122.18M | -93.67M | -85.66M |
| Selling general administrative | 20.85M | 29.91M | 31.75M | 22.27M | 23.23M |
| Reconciled depreciation | 1.56M | 2.06M | 2.22M | 2.03M | 1.76M |
| Ebit | - | -108.47M | -115.40M | -93.91M | -88.12M |
| Ebitda | - | -108.41M | -114.91M | -91.89M | -86.36M |
| Depreciation and amortization | - | 0.06M | 0.49M | 2.03M | 1.76M |
| Non operating income net other | - | - | -6.35M | -1.37M | 1.07M |
| Operating income | -74.33M | -108.47M | -115.40M | -91.89M | -86.36M |
| Other operating expenses | - | 108.47M | 115.40M | 91.89M | 86.36M |
| Interest expense | 5.48M | 4.67M | 3.61M | 2.11M | 1.05M |
| Tax provision | 0.91M | 0.93M | 0.43M | 0.41M | 0.19M |
| Interest income | - | - | - | - | 1.05M |
| Net interest income | -5.48M | -4.67M | -3.61M | -2.11M | 1.05M |
| Income tax expense | - | 0.93M | 0.43M | 0.41M | 0.19M |
| Total revenue | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 74.33M | 108.47M | 115.40M | 91.89M | 86.36M |
| Total other income expense net | -1.63M | -5.13M | -6.35M | -1.37M | 0.89M |
| Net income from continuing ops | -82.35M | -114.53M | -122.18M | -93.67M | -85.47M |
| Net income applicable to common shares | - | -114.53M | -122.18M | -93.67M | -85.47M |
| Breakdown | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 |
| Total assets | 64.44M | 87.87M | 90.64M | 90.92M | 159.87M |
| Other current assets | 3.63M | 2.58M | 2.12M | 3.18M | 3.70M |
| Total liab | 69.43M | 79.20M | 60.15M | 30.72M | 22.92M |
| Total stockholder equity | -4.99M | 8.67M | 30.48M | 60.20M | 136.95M |
| Deferred long term liab | - | 7.50M | - | 1.15M | 1.07M |
| Other current liab | 0.87M | 0.74M | 0.46M | 9.12M | 7.72M |
| Common stock | 0.11M | 0.05M | 0.05M | 0.03M | 0.03M |
| Capital stock | 0.11M | 0.05M | 0.05M | 0.03M | 0.03M |
| Retained earnings | -529.22M | -414.69M | -292.52M | -198.85M | -113.38M |
| Other liab | 8.16M | 7.50M | 0.28M | 1.35M | 1.38M |
| Other assets | 1.16M | 1.31M | 12.18M | 1.57M | 1.32M |
| Cash | 47.94M | 68.44M | 68.86M | 77.83M | 147.92M |
| Total current liabilities | 12.39M | 17.36M | 19.83M | 9.74M | 9.23M |
| Current deferred revenue | 7.50M | 13.07M | -2.14M | - | - |
| Net debt | 3.20M | -12.15M | -28.82M | -58.20M | -135.61M |
| Short term debt | 2.26M | 1.95M | 1.67M | - | - |
| Short long term debt total | 51.14M | 56.29M | 40.04M | 19.63M | 12.30M |
| Other stockholder equity | 524.12M | 423.31M | 322.96M | 259.02M | 90.45M |
| Property plant equipment | 11.71M | 6.62M | 7.48M | 8.34M | 6.92M |
| Total current assets | 51.57M | 71.03M | 68.86M | 77.83M | 147.92M |
| Net tangible assets | -4.99M | 8.67M | 30.48M | 60.20M | 136.95M |
| Short term investments | - | - | - | 0.00M | 54.82M |
| Long term debt | 43.61M | 46.56M | 30.05M | 19.63M | 12.30M |
| Accounts payable | 1.76M | 1.60M | 19.83M | 9.74M | 9.23M |
| Accumulated other comprehensive income | - | - | - | -90.92M | -0.02M |
| Common stock total equity | - | 0.05M | 0.05M | 0.03M | 0.03M |
| Retained earnings total equity | - | -414.69M | -292.52M | -198.85M | -113.38M |
| Non currrent assets other | 1.16M | 1.31M | 3.55M | 4.75M | 5.02M |
| Non current assets total | 12.87M | 16.84M | 21.78M | 13.09M | 11.95M |
| Capital lease obligations | 7.52M | 9.74M | 11.66M | - | - |
| Long term debt total | - | 46.56M | 30.05M | 19.63M | 12.30M |
| Breakdown | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
| Investments | 0.27M | -0.62M | -1.48M | -1.31M | 55.00M |
| Change to liabilities | - | 0.17M | -2.88M | 8.48M | 3.10M |
| Total cashflows from investing activities | - | -0.62M | -1.48M | -1.31M | 51.97M |
| Net borrowings | - | -3.12M | 14.78M | 10.00M | 4.48M |
| Total cash from financing activities | 20.76M | 81.66M | 97.54M | 65.47M | 4.99M |
| Change to operating activities | - | -9.84M | -5.59M | 6.93M | 4.06M |
| Net income | -82.35M | -114.53M | -122.18M | -93.67M | -85.47M |
| Change in cash | -52.15M | -20.66M | -0.67M | -8.91M | -15.02M |
| Begin period cash flow | 70.21M | 69.75M | 70.42M | 79.33M | 94.35M |
| End period cash flow | 17.54M | 49.10M | 69.75M | 70.42M | 79.33M |
| Total cash from operating activities | -73.70M | -101.23M | -96.72M | -73.06M | -71.98M |
| Issuance of capital stock | 29.17M | 84.54M | 81.75M | 54.99M | 0.00M |
| Depreciation | 1.56M | 2.06M | 2.22M | 2.03M | 1.76M |
| Other cashflows from investing activities | - | - | 0.04M | 0.01M | 0.00M |
| Sale purchase of stock | - | - | 1.01M | 55.47M | 0.51M |
| Other cashflows from financing activities | - | 44.72M | 15.79M | 10.47M | 19.99M |
| Change to netincome | - | 20.90M | 19.32M | 8.84M | 8.42M |
| Capital expenditures | 0.29M | 0.62M | 1.52M | 1.32M | 3.03M |
| Cash flows other operating | - | - | 6.80M | 1.26M | 0.37M |
| Cash and cash equivalents changes | - | - | -0.67M | -8.91M | -15.02M |
| Change in working capital | -11.79M | -9.67M | 2.07M | 7.76M | 3.47M |
| Stock based compensation | 11.17M | 15.16M | 15.85M | 8.47M | 8.16M |
| Other non cash items | 5.73M | 5.74M | 2.10M | 2.35M | 0.26M |
| Free cash flow | -73.99M | -101.86M | -98.24M | -74.38M | -75.01M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|
| EVLO Evelo Biosciences Inc |
- -% |
0.00 | - | - | - | 3.51 | -0.39 |
| NVO Novo Nordisk A/S |
0.01 0.02% |
40.31 | 41.58 | 31.15 | 2.13 | 32.99 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
4.59 0.85% |
547.09 | 30.22 | 24.27 | 10.36 | 6.50 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
1.45 0.16% |
904.35 | 29.07 | 20.12 | 7.57 | 3.82 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 36.06 |
Evelo Biosciences, Inc., a clinical-stage biotechnology company, focuses on discovering and developing oral medicines that act on immune cells in the small intestine with systemic effects. It is developing EDP1815, a whole-microbe product candidate, which has completed a Phase 2 trial for the treatment of psoriasis . The company is also developing EDP1867, a non-live pharmaceutical preparation for single strain of Veillonella parvula, which is in Phase 1b clinical trial; EDP2939, an investigational oral biologic for the potential treatment of inflammatory diseases; and EDP1908, a product candidate for oncology. Evelo Biosciences, Inc. was incorporated in 2014 and is headquartered in Cambridge, Massachusetts.
600/700, One Kendall Square, Cambridge, MA, United States, 02139
617 577 0300
66
| Name | Title | Year Born |
|---|---|---|
| Dr. Balkrishan Gill Ph.D. | Pres, CEO & Director | 1965 |
| Dr. Jonathan B. Zung Ph.D. | Chief Devel. Officer | 1965 |
| Ms. Marella Thorell | CFO & Treasurer | 1967 |
| Mr. Stephen J. Carriere | VP & Chief Accounting Officer | 1955 |
| Dr. Chun Zhang Ph.D. | Chief Technical Operations & Quality Officer | NA |
| Dr. Mark Bodmer Ph.D. | Chief Scientific Officer and Pres of R&D | 1958 |
| Ms. Kendra Sweeney | Head of Investor Relations & Capital Markets | NA |
| Ms. Jessica Cotrone | VP & Head of Communications | NA |
| Ms. Leslie Wardwell-Scott Ph.D. | VP and Head of Corp. Devel. & Strategic Integration | NA |
| Ms. Julie Carretero | Chief People Officer | NA |
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