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Inovio Pharmaceuticals, Inc., a biotechnology company, focuses on the discovery, development, and commercialization of DNA medicines to treat and protect people from diseases associated with human papillomavirus (HPV), cancer, and infectious diseases. Its DNA medicines platform uses SynCon, to help engineer precisely designed plasmid DNA plasmids, as well as CELLECTRA smart devices technology that facilitates delivery of the DNA plasmids. The company's lead product candidate is INO-3107 for HPV-related recurrent respiratory papillomatosis and is under Phase 1/2 trial. Its products in pipeline include VGX-3100 for the treatment of HPV-related cervical high-grade squamous intraepithelial lesions; INO-3112 for the treatment of HPV-related Oropharyngeal squamous cell carcinoma and is under Phase 2 trial; INO-5401 for the treatment of glioblastoma multiforme and is under Phase 2 trial; INO-4201 for Ebola Virus Disease and is under Phase 1b trial; INO-4800 for COVID-19 and is under Phase 2/3 trial; and INO-6160 for the treatment of human immunodeficiency virus and is under Phase 1 trial. The company's partners and collaborators ApolloBio Corporation, AstraZeneca, Coherus Biosciences, Defense Advanced Research Projects Agency, HIV Vaccines Trial Network, Kaneka Eurogentec, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Plumbline Life Sciences, Regeneron Pharmaceuticals, Richter BioLogics, the University of Pennsylvania, and The Wistar Institute. The company was incorporated in 1983 and is headquartered in Plymouth Meeting, Pennsylvania.
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Inovio Pharmaceuticals is a clinical-stage biotechnology company developing DNA-based vaccines and immunotherapies delivered via its proprietary electroporation device, pursuing programs for infectious diseases and cancer. Long-term growth may be driven by successful clinical readouts and approvals, strategic partnerships to scale commercialization, and broader adoption of DNA platforms for rapid vaccine design.
Material risks include its early-stage profile with no marketed product, high cash burn and potential dilution, substantial execution and regulatory risk from clinical trial failures, and strong competition from mRNA and viral-vector platforms.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -84.95M | -107.25M | -135.12M | -277.65M | -303.22M |
| Minority interest | - | - | - | 0.00M | 0.00M |
| Net income | -84.95M | -107.25M | -135.12M | -287.66M | -305.38M |
| Selling general administrative | 32.68M | 36996.34M | 47.58M | 90.19M | 53.75M |
| Selling and marketing expenses | - | 36959.34M | 3.50M | - | - |
| Gross profit | 0.07M | -2.91M | 0.83M | 10.26M | 1.77M |
| Reconciled depreciation | 2.99M | 3.13M | 4.68M | 5.50M | 4.73M |
| Ebit | -84.95M | -107.08M | -133.89M | -267.57M | -301.22M |
| Ebitda | -81.96M | -103.95M | -130.39M | -268.55M | -293.33M |
| Depreciation and amortization | 2.99M | 3.13M | 3.50M | -0.98M | 7.88M |
| Non operating income net other | - | - | - | -1.24M | 3.27M |
| Operating income | -86.82M | -112.40M | -143.94M | -267.57M | -301.22M |
| Other operating expenses | 86.89M | 112.62M | 144.77M | 277.84M | 302.99M |
| Interest expense | 0.00M | 0.18M | 1.22M | 1.25M | 1.94M |
| Tax provision | - | - | - | - | 0.00M |
| Interest income | 2.42M | 4.77M | 8.20M | 4.78M | 3.36M |
| Net interest income | 2.42M | 4.59M | 6.95M | 3.53M | 1.43M |
| Income tax expense | - | -107146.87M | 0.00M | 10.01M | 2.16M |
| Total revenue | 0.07M | 0.22M | 0.83M | 10.26M | 1.77M |
| Total operating expenses | 86.89M | 111.09M | 144.77M | 277.84M | 302.99M |
| Cost of revenue | 2.99M | 3.13M | 3.50M | - | - |
| Total other income expense net | 1.88M | -107141.73M | 8.82M | -10.08M | -2.01M |
| Net income from continuing ops | -84.95M | -107.25M | -164.58M | -277.65M | -303.22M |
| Net income applicable to common shares | - | -107.25M | -135.12M | -279.82M | -303.66M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 74.31M | 113.20M | 172.94M | 348.53M | 495.94M |
| Intangible assets | - | - | - | 2.13M | 2.63M |
| Other current assets | 2.61M | 2.52M | 5.41M | 50.51M | 39.10M |
| Total liab | 50.21M | 44.69M | 55.60M | 126.17M | 96.27M |
| Total stockholder equity | 24.10M | 68.50M | 117.35M | 222.36M | 399.67M |
| Deferred long term liab | - | - | - | 0.03M | - |
| Other current liab | 38.23M | 26.39M | 18.74M | 13.16M | 38.35M |
| Common stock | 0.07M | 0.04M | 0.02M | 0.25M | 0.22M |
| Capital stock | 0.07M | 0.04M | 0.02M | 0.25M | 0.22M |
| Retained earnings | -1815.17M | -1730.22M | -1622.97M | -1487.85M | -1209.86M |
| Other liab | - | - | - | 0.03M | 0.11M |
| Good will | - | - | 0.00M | 10.51M | 10.51M |
| Other assets | - | -1.70M | 0.00M | 0.68M | 1.43M |
| Cash | 44.27M | 65.81M | 14.31M | 46.33M | 71.14M |
| Total current liabilities | 43.67M | 35.33M | 42.57M | 96.87M | 65.74M |
| Current deferred revenue | - | - | - | - | 0.02M |
| Net debt | -34.91M | -53.95M | 15.90M | -14.25M | -38.12M |
| Short term debt | 2.82M | 2.50M | 19.18M | 2.80M | 2.60M |
| Short long term debt | - | - | 16.77M | - | - |
| Short long term debt total | 9.37M | 11.87M | 30.21M | 32.07M | 33.02M |
| Other stockholder equity | 1839.83M | 1799.36M | 1740.95M | 1710.66M | 1609.59M |
| Property plant equipment | - | - | - | 7.73M | 17.45M |
| Total current assets | 61.12M | 97.83M | 153.11M | 315.24M | 448.44M |
| Long term investments | 2.10M | 1.61M | 2.78M | 2.01M | 3.91M |
| Net tangible assets | - | - | - | 209.72M | 386.53M |
| Short term investments | 14.24M | 28.30M | 130.98M | 206.67M | 330.17M |
| Net receivables | 0.00M | 1.20M | 2.41M | 11.74M | 8.03M |
| Long term debt | - | - | - | 16.61M | 14.96M |
| Accounts payable | 2.62M | 6.44M | 4.65M | 80.91M | 24.76M |
| Accumulated other comprehensive income | -0.64M | -0.68M | -0.66M | -0.70M | -0.28M |
| Common stock total equity | - | - | - | 0.25M | 0.22M |
| Retained earnings total equity | - | - | - | -1487.85M | -1209.86M |
| Non currrent assets other | 2.01M | 1.98M | 0.61M | 0.68M | 1.43M |
| Non current assets total | 13.19M | 15.37M | 19.83M | 33.29M | 47.50M |
| Capital lease obligations | 9.37M | 11.87M | 13.44M | 15.46M | 18.06M |
| Long term debt total | - | - | - | 16.61M | - |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | 14.33M | 104.07M | 121.41M | 112.56M | -174.11M |
| Change to liabilities | - | - | - | 32.59M | 26.10M |
| Total cashflows from investing activities | 14.04M | 104.07M | 87.36M | 109.59M | -175.34M |
| Net borrowings | 0.00M | -16.41M | 0.00M | - | - |
| Total cash from financing activities | 53.05M | 51.48M | 5.00M | 81.84M | 211.50M |
| Change to operating activities | - | - | - | -6.95M | 16.19M |
| Net income | -84.95M | -107.25M | -135.12M | -279.82M | -303.66M |
| Change in cash | -21.54M | 51.50M | -32.02M | -24.81M | -179.58M |
| Begin period cash flow | 65.81M | 14.31M | 46.33M | 71.14M | 250.73M |
| End period cash flow | 44.27M | 65.81M | 14.31M | 46.33M | 71.14M |
| Total cash from operating activities | -88.63M | -104.08M | -124.37M | -216.22M | -215.71M |
| Issuance of capital stock | 34.91M | 36.03M | 10.29M | 82.96M | 209.44M |
| Depreciation | 2.99M | 3.13M | 3.50M | 5.50M | 4.73M |
| Other cashflows from investing activities | -1176.33M | 0.06M | 6.22M | -2.00M | - |
| Change to inventory | - | - | - | - | 15.55M |
| Change to account receivables | - | 1.21M | 9.33M | -3.71M | 11.03M |
| Sale purchase of stock | - | - | - | 82.96M | 209.44M |
| Other cashflows from financing activities | -0.11M | -0.42M | -0.47M | -1.11M | 2.06M |
| Change to netincome | - | - | - | 30.01M | 27.46M |
| Capital expenditures | 0.29M | 0.49M | 0.32M | 0.97M | 1.23M |
| Change receivables | - | - | - | -3.71M | 11.03M |
| Cash flows other operating | - | - | - | 1.87M | 18.17M |
| Cash and cash equivalents changes | - | - | - | -24.79M | -179.55M |
| Change in working capital | -9.22M | -2.66M | -10.26M | 19.83M | 50.35M |
| Stock based compensation | 3.76M | 6.60M | 11.07M | 22.56M | 26.34M |
| Other non cash items | -1.21M | -3.88M | 6.47M | 15.72M | 0.86M |
| Free cash flow | -88.92M | -104.56M | -124.69M | -217.18M | -216.94M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| INO Inovio Pharmaceuticals Inc |
0.20 16.05% |
1.41 | - | 16.58 | 961.51 | 27.91 | 921.12 | -1.09 |
| NVO Novo Nordisk A/S |
0.47 1.18% |
40.78 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
4.59 0.85% |
547.09 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
1.45 0.16% |
904.35 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Inovio Pharmaceuticals, Inc., a biotechnology company, focuses on the discovery, development, and commercialization of DNA medicines to treat and protect people from diseases associated with human papillomavirus (HPV), cancer, and infectious diseases. Its DNA medicines platform uses SynCon, to help engineer precisely designed plasmid DNA plasmids, as well as CELLECTRA smart devices technology that facilitates delivery of the DNA plasmids. The company's lead product candidate is INO-3107 for HPV-related recurrent respiratory papillomatosis and is under Phase 1/2 trial. Its products in pipeline include VGX-3100 for the treatment of HPV-related cervical high-grade squamous intraepithelial lesions; INO-3112 for the treatment of HPV-related Oropharyngeal squamous cell carcinoma and is under Phase 2 trial; INO-5401 for the treatment of glioblastoma multiforme and is under Phase 2 trial; INO-4201 for Ebola Virus Disease and is under Phase 1b trial; INO-4800 for COVID-19 and is under Phase 2/3 trial; and INO-6160 for the treatment of human immunodeficiency virus and is under Phase 1 trial. The company's partners and collaborators ApolloBio Corporation, AstraZeneca, Coherus Biosciences, Defense Advanced Research Projects Agency, HIV Vaccines Trial Network, Kaneka Eurogentec, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Plumbline Life Sciences, Regeneron Pharmaceuticals, Richter BioLogics, the University of Pennsylvania, and The Wistar Institute. The company was incorporated in 1983 and is headquartered in Plymouth Meeting, Pennsylvania.
660 West Germantown Pike, Plymouth Meeting, PA, United States, 19462
267 440 4200
112
| Name | Title | Year Born |
|---|---|---|
| Dr. Jacqueline E. Shea Ph.D. | CEO, Pres & Director | 1966 |
| Mr. Peter D. Kies | Chief Financial Officer | 1963 |
| Dr. Laurent M. Humeau Ph.D. | Chief Scientific Officer | 1967 |
| Ben Matone | Director of Investor Relations | NA |
| Mr. Robert L. Crotty J.D. | Gen. Counsel | 1974 |
| Ms. Asli Gevgilili | Chief HR Officer | NA |
| Mr. E. J. Brandreth MBA | Sr. VP of Quality Assurance | NA |
| Dr. Jeffrey Skolnik | Sr. VP of Clinical Devel. | NA |
| Mr. Robert J. Juba Jr. | Sr. VP of Biological Manufacturing & Clinical Supply Management | NA |
| Mr. Daniel Jordan | Sr. VP of Device Manufacturing Operations | NA |
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