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Aptose Biosciences Inc., a clinical-stage biotechnology company, discovers and develops precision medicines addressing unmet medical needs in oncology primarily in the United States. The company's clinical-stage oral kinase inhibitors include tuspetinib (HM43239), a once-daily oral kinase inhibitor that has completed Phase 1/2 clinical trial targeting a select group of kinases operative in myeloid malignancies, such as acute myeloid leukemia and the higher risk myelodysplastic syndromes; and luxeptinib (CG-806), a potent oral small molecule, which is in Phase 1 a/b clinical trial in patients with relapsed or refractory B cell malignancies, including chronic lymphocytic leukemia, and certain non-Hodgkin's lymphomas, as well as relapsed or refractory acute myeloid leukemia. It has license agreements with CrystalGenomics Invites Co. Ltd. to research, develop, and commercialize luxeptinib; with National Cancer Institute for the clinical development of tuspetinib; and Hanmi Pharmaceutical Co Ltd. to research, develop, and commercialize tuspetinib. The company was formerly known as Lorus Therapeutics Inc. and changed its name to Aptose Biosciences Inc. in August 2014. Aptose Biosciences Inc. was incorporated in 1986 and is headquartered in Toronto, Canada.
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| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -25.91M | -25.43M | -51.21M | -41.82M | -65.35M |
| Net income | -25.91M | -25.43M | -51.21M | -41.05M | -65.26M |
| Selling general administrative | - | 11.15M | 15.59M | 14.43M | 19.32M |
| Gross profit | -0.43M | - | -0.47M | - | - |
| Reconciled depreciation | - | 0.40M | 0.47M | 0.53M | 0.62M |
| Ebit | -25.16M | -26.26M | -52.36M | -42.59M | -65.45M |
| Ebitda | -24.73M | -26.23M | -52.27M | -42.06M | -64.82M |
| Depreciation and amortization | 0.43M | 0.03M | 0.09M | 0.53M | 0.62M |
| Operating income | -25.16M | -26.26M | -52.36M | -42.59M | -65.45M |
| Other operating expenses | 25.16M | 26.26M | 52.36M | 42.60M | 65.45M |
| Interest expense | 0.86M | -0.21M | 0.00M | 0.77M | 0.09M |
| Interest income | - | 0.36M | 1.15M | 0.78M | 0.09M |
| Net interest income | - | 0.15M | 1.15M | 0.79M | 0.09M |
| Income tax expense | - | - | - | -0.77M | -0.09M |
| Total revenue | - | 0.00M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 24.73M | 26.26M | 52.36M | 42.60M | 65.45M |
| Cost of revenue | 0.43M | - | 0.47M | - | - |
| Total other income expense net | -0.76M | 0.83M | 1.15M | 0.77M | 0.09M |
| Net income from continuing ops | - | -25.43M | -51.21M | -41.82M | -65.35M |
| Net income applicable to common shares | - | - | - | -41.82M | -65.35M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 9.99M | 10.13M | 12.99M | 51.03M | 82.53M |
| Other current assets | 2.35M | 0.57M | 0.60M | 0.26M | 0.13M |
| Total liab | 37.11M | 14.67M | 15.89M | 13.29M | 8.29M |
| Total stockholder equity | -27.12M | -4.54M | -2.90M | 37.74M | 74.24M |
| Other current liab | 9.10M | - | 11.38M | 5.66M | 6.02M |
| Common stock | 458.93M | - | 444.81M | 437.52M | 437.39M |
| Capital stock | - | 457.40M | 444.81M | 437.52M | 437.39M |
| Retained earnings | -565.40M | -540.97M | -515.54M | -464.33M | -422.51M |
| Cash | 4.09M | 6.15M | 9.25M | 36.97M | 39.11M |
| Cash and equivalents | - | - | - | 36.37M | 38.82M |
| Total current liabilities | 9.29M | 4.46M | 15.27M | 12.28M | 8.17M |
| Net debt | 23.93M | 3.87M | -8.24M | -35.67M | -38.54M |
| Short term debt | 0.19M | - | 0.39M | 0.30M | 0.46M |
| Short long term debt total | 28.01M | - | 1.01M | 1.30M | 0.57M |
| Other stockholder equity | 83.66M | - | 72.15M | 68.87M | 63.67M |
| Property plant equipment | - | - | - | 1.51M | 0.79M |
| Total current assets | 6.43M | 9.53M | 11.89M | 49.52M | 81.74M |
| Net tangible assets | - | - | - | - | 74.24M |
| Short term investments | - | - | 0.00M | 9.99M | 40.01M |
| Long term debt | - | 10.02M | - | - | - |
| Accounts payable | - | 1.26M | 3.49M | 6.33M | 1.70M |
| Accumulated other comprehensive income | -4.31M | - | -4.32M | -4.32M | -4.32M |
| Non currrent assets other | 3.38M | - | - | - | - |
| Non current assets total | 3.56M | 0.60M | 1.09M | 1.51M | 0.79M |
| Capital lease obligations | - | 0.62M | 1.01M | 1.30M | 0.57M |
| Long term debt total | - | - | - | 0.00M | 0.00M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | - | 0.02M | 9.96M | 30.07M | -35.00M |
| Change to liabilities | - | - | - | 0.00M | -0.47M |
| Total cashflows from investing activities | - | 0.02M | 9.96M | 30.07M | -35.21M |
| Net borrowings | - | 10.00M | 0.00M | - | - |
| Total cash from financing activities | 19.72M | 33.41M | 6.91M | 0.12M | 0.23M |
| Change to operating activities | - | - | - | - | 1.43M |
| Net income | -25.91M | -25.43M | -51.21M | -41.82M | -65.35M |
| Change in cash | -2.94M | -2.54M | -27.72M | -2.14M | -78.28M |
| Begin period cash flow | 7.02M | 9.25M | 36.97M | 39.11M | 117.39M |
| End period cash flow | 4.09M | 6.71M | 9.25M | 36.97M | 39.11M |
| Total cash from operating activities | -22.37M | -35.98M | -44.59M | -32.32M | -43.30M |
| Issuance of capital stock | - | 23.41M | 6.88M | 0.10M | 0.04M |
| Depreciation | 0.43M | 0.40M | 0.47M | 0.53M | 0.62M |
| Other cashflows from investing activities | - | 0.02M | - | 30.09M | -35.00M |
| Sale purchase of stock | - | 0.03M | - | 0.12M | 0.23M |
| Other cashflows from financing activities | - | 0.03M | 0.03M | 0.01M | 0.19M |
| Change to netincome | - | - | - | - | 20.47M |
| Capital expenditures | 0.00M | 0.01M | 0.03M | 0.02M | 0.21M |
| Change in working capital | 1.74M | -11.03M | 2.81M | 4.32M | 1.52M |
| Stock based compensation | - | 1.06M | 3.65M | 5.21M | 12.95M |
| Other non cash items | 1.38M | -0.99M | -0.19M | -0.55M | 6.96M |
| Free cash flow | -22.37M | -35.98M | -44.62M | -32.35M | -43.52M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(CAD) |
Price
(CAD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| EPRX Eupraxia Pharmaceuticals Inc |
0.03 0.31% |
9.68 | - | - | - | 8.45 | - | -3.88 |
| FRX Fennec Pharmaceuticals Inc |
0.20 1.35% |
14.99 | - | 21.01 | 6.95 | 6.35 | 4.25 | 20.27 |
| MSCL Satellos Bioscience Inc. |
- -% |
9.00 | - | - | - | 5.85 | - | 6.47 |
| HBP Helix BioPharma Corp. |
-0.10 9.80% |
0.92 | - | 3.87 | 4263.36 | 9.74 | 4422.35 | -6.36 |
Aptose Biosciences Inc., a clinical-stage biotechnology company, discovers and develops precision medicines addressing unmet medical needs in oncology primarily in the United States. The company's clinical-stage oral kinase inhibitors include tuspetinib (HM43239), a once-daily oral kinase inhibitor that has completed Phase 1/2 clinical trial targeting a select group of kinases operative in myeloid malignancies, such as acute myeloid leukemia and the higher risk myelodysplastic syndromes; and luxeptinib (CG-806), a potent oral small molecule, which is in Phase 1 a/b clinical trial in patients with relapsed or refractory B cell malignancies, including chronic lymphocytic leukemia, and certain non-Hodgkin's lymphomas, as well as relapsed or refractory acute myeloid leukemia. It has license agreements with CrystalGenomics Invites Co. Ltd. to research, develop, and commercialize luxeptinib; with National Cancer Institute for the clinical development of tuspetinib; and Hanmi Pharmaceutical Co Ltd. to research, develop, and commercialize tuspetinib. The company was formerly known as Lorus Therapeutics Inc. and changed its name to Aptose Biosciences Inc. in August 2014. Aptose Biosciences Inc. was incorporated in 1986 and is headquartered in Toronto, Canada.
| Name | Title | Year Born |
|---|---|---|
| Dr. William G. Rice Ph.D. | Chairman, Pres, CEO & Chief Accounting Officer | 1959 |
| Dr. Rafael Bejar M.D., Ph.D. | Sr. VP & Chief Medical Officer | 1972 |
| Ms. Janet Clennett C.A. | VP of Fin. | NA |
| Mr. Fletcher Payne | Sr. VP & CFO | 1963 |
| Mr. Roger Davies B.Sc. | VP of Operations | NA |
| Mr. Philippe Ledru | Sr. VP & Chief Commercial Officer | NA |
| Dr. William G. Rice Ph.D. | Chairman, President & CEO | 1959 |
| Mr. Fletcher Payne | Senior VP, CFO, Chief Business Officer & Secretary | 1963 |
| Dr. Rafael Bejar M.D., Ph.D. | Senior VP & Chief Medical Officer | 1972 |
| Dr. Marc Wiles Ph.D. | Senior Vice President of Regulatory Affairs | NA |
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