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Edgewise Therapeutics, Inc., a biopharmaceutical company, discovers, develops, and commercializes therapies for the treatment of muscle disorders. Its lead product candidate, sevasemten, an orally administered small molecule that is in Phase II clinical trials, designed to address the root cause of dystrophinopathies including Duchenne muscular dystrophy and Becker muscular dystrophy. The company develops EDG-7500, a small molecule for the treatment of hypertrophic cardiomyopathy and other severe cardiac disorders that is in Phase I clinical trials; and EDG-15400, a novel small molecule for the treatment of heart failure with preserved ejection fraction. In addition, it develops a pipeline of precision medicine product candidates that target key muscle proteins and modulators to address genetically defined muscle disorders. The company was incorporated in 2017 and is headquartered in Boulder, Colorado.
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Edgewise Therapeutics is a clinical-stage biopharmaceutical company focused on developing treatments for rare neuromuscular and muscle-wasting disorders. Its long-term growth drivers include successful progression of clinical programs, regulatory approvals and strategic partnerships to commercialize therapies, and it may benefit from significant unmet medical need in its target indications.
The most important investment risks are trial and regulatory failure, limited operating history with negligible product revenue, and the likely need for additional financing that could dilute shareholders.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -167.79M | -133.81M | -100.16M | -19.41M | -42.81M |
| Net income | -167.79M | -133.81M | -100.16M | -15.40M | -42.14M |
| Selling general administrative | 40.02M | 31.87M | 23.45M | 5.47M | 11.03M |
| Selling and marketing expenses | - | - | 0.18M | - | - |
| Gross profit | -2.27M | -2.29M | -1.73M | - | - |
| Reconciled depreciation | 2.27M | 2.29M | 1.73M | 0.54M | 0.27M |
| Ebit | -167.79M | -158.83M | -114.36M | -22.62M | -43.49M |
| Ebitda | -165.53M | -156.54M | -112.62M | -22.08M | -43.22M |
| Depreciation and amortization | 2.27M | 2.29M | 1.73M | 0.54M | 0.27M |
| Non operating income net other | - | - | - | 4.02M | 0.40M |
| Operating income | -191.41M | -158.83M | -114.36M | -22.08M | -43.22M |
| Other operating expenses | 191.41M | 158.83M | 114.36M | 22.08M | 43.22M |
| Interest expense | - | - | - | 4.02M | 0.27M |
| Interest income | 23.61M | 25.02M | 14.19M | 4.02M | 0.40M |
| Net interest income | 23.61M | 25.02M | 14.19M | 4.02M | 0.40M |
| Income tax expense | - | -0.00M | - | -4.02M | -0.67M |
| Total revenue | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 189.14M | 158.83M | 114.36M | 22.08M | 43.22M |
| Cost of revenue | 2.27M | 2.29M | 1.73M | - | - |
| Total other income expense net | 23.61M | 25.02M | 14.19M | 2.66M | 0.40M |
| Net income from continuing ops | -167.79M | -133.81M | -100.16M | -67.64M | -42.81M |
| Net income applicable to common shares | - | - | - | -67.64M | -42.81M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 552.60M | 486.82M | 340.04M | 367.10M | 285.23M |
| Other current assets | 13.28M | 5.31M | 8.60M | 5.05M | 2.98M |
| Total liab | 30.35M | 27.60M | 21.20M | 20.39M | 10.85M |
| Total stockholder equity | 522.26M | 459.22M | 318.83M | 346.72M | 274.38M |
| Deferred long term liab | - | - | - | 0.25M | - |
| Other current liab | 20.35M | 17.29M | 11.77M | 9.87M | 6.68M |
| Common stock | 0.01M | 0.01M | 0.01M | 0.01M | 0.01M |
| Capital stock | 0.01M | 0.01M | 0.01M | 0.01M | 0.01M |
| Retained earnings | -546.37M | -378.58M | -244.76M | -144.60M | -76.96M |
| Other liab | - | - | - | - | 0.33M |
| Other assets | - | - | - | 0.25M | 0.55M |
| Cash | 61.15M | 41.67M | 86.10M | 351.95M | 280.79M |
| Total current liabilities | 27.37M | 23.86M | 16.77M | 16.59M | 10.52M |
| Net debt | -57.16M | -36.93M | -80.68M | -347.54M | -280.79M |
| Short term debt | 1.01M | 1.00M | 0.98M | 0.61M | - |
| Short long term debt total | 3.99M | 4.74M | 5.41M | 4.41M | - |
| Other stockholder equity | 1067.94M | 837.36M | 563.49M | 492.67M | 66.62M |
| Property plant equipment | - | - | - | 8.53M | 0.91M |
| Total current assets | 543.38M | 475.48M | 327.00M | 351.95M | 280.79M |
| Net tangible assets | - | - | - | 346.72M | 274.38M |
| Short term investments | 468.96M | 428.50M | 232.30M | 329.95M | 265.22M |
| Net receivables | - | - | - | 0.25M | 0.55M |
| Accounts payable | 6.01M | 5.58M | 4.03M | 6.11M | 3.84M |
| Accumulated other comprehensive income | 0.68M | 0.42M | 0.10M | -1.35M | -0.51M |
| Common stock total equity | - | - | - | 0.01M | 0.01M |
| Retained earnings total equity | - | - | - | -144.60M | -76.96M |
| Non currrent assets other | - | 0.26M | 0.35M | 5.30M | 3.53M |
| Non current assets total | 9.22M | 11.33M | 13.04M | 15.15M | 4.44M |
| Capital lease obligations | 3.99M | 4.74M | 5.41M | 4.41M | - |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | -32.53M | -184.66M | 0.31M | -70.58M | -241.56M |
| Change to liabilities | - | - | - | 2.62M | 7.02M |
| Total cashflows from investing activities | -32.79M | -184.66M | 102.89M | -70.58M | -242.23M |
| Net borrowings | - | - | - | -0.25M | - |
| Total cash from financing activities | 196.09M | 249.25M | 53.17M | 129.64M | 186.38M |
| Change to operating activities | - | - | - | 4.04M | 1.98M |
| Net income | -167.79M | -133.81M | -100.16M | -67.64M | -42.81M |
| Change in cash | 19.48M | -44.43M | 64.10M | 6.43M | -89.35M |
| Begin period cash flow | 41.67M | 86.10M | 21.99M | 15.57M | 104.92M |
| End period cash flow | 61.15M | 41.67M | 86.10M | 21.99M | 15.57M |
| Total cash from operating activities | -143.82M | -109.03M | -91.95M | -52.63M | -33.51M |
| Issuance of capital stock | 187.36M | 239.15M | -0.56M | 129.16M | 186.15M |
| Depreciation | 2.27M | 2.29M | 1.73M | 0.54M | 0.27M |
| Other cashflows from investing activities | -32.79M | - | - | - | - |
| Sale purchase of stock | - | - | - | 129.89M | 186.38M |
| Other cashflows from financing activities | 196.09M | 10.11M | 0.55M | 0.47M | 0.24M |
| Change to netincome | - | - | - | 10.92M | 4.40M |
| Capital expenditures | 0.26M | 1.31M | 5.75M | 5.55M | 0.67M |
| Cash flows other operating | - | - | - | 1.64M | -2.39M |
| Cash and cash equivalents changes | - | - | - | 6.43M | -89.35M |
| Change in working capital | -5.37M | 10.33M | -1.56M | 4.09M | 4.63M |
| Stock based compensation | 34.75M | 24.71M | 17.56M | 10.92M | 4.40M |
| Other non cash items | 27.09M | -12.54M | -9.52M | -0.54M | -228.94M |
| Free cash flow | -143.82M | -110.34M | -97.69M | -58.18M | -34.17M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|
| EWTX Edgewise Therapeutics Inc |
1.52 3.39% |
46.56 | - | - | - | 6.98 | -2.60 |
| NVO Novo Nordisk A/S |
1.03 2.56% |
41.34 | 41.58 | 31.15 | 2.13 | 32.99 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
1.49 0.27% |
548.58 | 30.22 | 24.27 | 10.36 | 6.50 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
18.16 2.01% |
922.51 | 29.07 | 20.12 | 7.57 | 3.82 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 36.06 |
Edgewise Therapeutics, Inc., a biopharmaceutical company, discovers, develops, and commercializes therapies for the treatment of muscle disorders. Its lead product candidate, sevasemten, an orally administered small molecule that is in Phase II clinical trials, designed to address the root cause of dystrophinopathies including Duchenne muscular dystrophy and Becker muscular dystrophy. The company develops EDG-7500, a small molecule for the treatment of hypertrophic cardiomyopathy and other severe cardiac disorders that is in Phase I clinical trials; and EDG-15400, a novel small molecule for the treatment of heart failure with preserved ejection fraction. In addition, it develops a pipeline of precision medicine product candidates that target key muscle proteins and modulators to address genetically defined muscle disorders. The company was incorporated in 2017 and is headquartered in Boulder, Colorado.
| Name | Title | Year Born |
|---|---|---|
| Dr. Kevin Koch Ph.D. | Pres, CEO & Director | 1960 |
| Dr. Badreddin Edris Ph.D. | Co-Founder & Independent Director | 1987 |
| Dr. Behrad Derakhshan Ph.D. | Chief Bus. Officer | 1980 |
| Dr. Joanne M. Donovan M.D., Ph.D. | Chief Medical Officer | 1957 |
| Dr. Alan J. Russell Ph.D. | Co-Founder, Chief Scientific Officer & Director | 1970 |
| Mr. R. Michael Carruthers | Chief Financial Officer | 1958 |
| Mr. John R. Moore | Gen. Counsel | 1964 |
| Dr. Peter A. Thompson FACP, M.D. | Co-Founder & Independent Chairman | 1960 |
| Dr. Kevin Koch Ph.D. | President, CEO & Director | 1960 |
| Dr. Badreddin Edris Ph.D. | Co-Founder & Independent Director | 1988 |
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