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Jaguar Health, Inc., a commercial-stage pharmaceuticals company, focuses on developing plant-based prescription medicines for people and animals with gastrointestinal distress. It operates through two segments, Animal Health and Human Health. The company focuses on developing and commercializing prescription and non-prescription products for companion and production animals; and human products. Its lead prescription drug is Mytesi, an anti-secretory antidiarrheal drug for the symptomatic relief of non-infectious diarrhea in adults with HIV/AIDS on antiretroviral therapy; and Canalevia-CA1, a prescription drug product for chemotherapy-induced diarrhea in dogs. It is also developing Crofelemer, an anti-secretory antidiarrheal drug, which is in Phase III clinical trial for prophylaxis of diarrhea in adult cancer patients; Phase II clinical trials for rare/orphan disease indications, including short bowel syndrome with intestinal failure and microvillus inclusion disease; diarrhea-predominant irritable bowel syndrome; and for idiopathic/functional diarrhea. In addition, the company is developing Mytesi which is in Phase III clinical trial for cancer therapy-related diarrhea, as well as Phase II clinical trial for irritable bowel syndrome; and NP-300, a second-generation antidiarrheal drug that is in Phase I clinical trial for symptomatic relief and treatment of moderate-to-severe diarrhea. The company is headquartered in San Francisco, California.
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Jaguar Animal Health Inc is a U.S.-based animal health company focused on developing and commercializing therapeutics and products for veterinary use. Its long-term growth may be driven by gaining regulatory approvals for pipeline products, expanding commercial distribution, and licensing or partnerships, which could support revenue diversification and scale.
Principal risks include regulatory and clinical development failure, competition from larger animal-health companies, and limited operating scale and liquidity that could constrain commercialization and require additional financing.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -54.00M | -39.25M | -41.90M | -48.40M | -52.60M |
| Minority interest | 0.56M | 0.76M | 1.11M | 0.94M | 0.01M |
| Net income | -53.43M | -38.49M | -41.30M | -47.45M | -60.25M |
| Selling general administrative | 21.85M | 16.33M | 16.59M | 17.87M | 17.10M |
| Selling and marketing expenses | 4.17M | 7.69M | 6.46M | 8.84M | 8.89M |
| Gross profit | 7.74M | 9.73M | 7.72M | 9.94M | 2.00M |
| Reconciled depreciation | 2.20M | 2.36M | 2.40M | 2.29M | 1.81M |
| Ebit | -53.93M | -39.02M | -33.92M | -34.41M | -39.07M |
| Ebitda | -51.73M | -36.66M | -32.76M | -31.17M | -39.66M |
| Depreciation and amortization | 2.20M | 2.36M | 1.16M | 3.24M | -0.59M |
| Operating income | -45.11M | -30.83M | -34.29M | -34.41M | -39.07M |
| Other operating expenses | 56.62M | 42.52M | 44.05M | 46.37M | 43.41M |
| Interest expense | 0.07M | 0.23M | 6.38M | 12.72M | 8.42M |
| Tax provision | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Net interest income | -0.07M | -0.23M | -8.77M | -12.72M | -10.05M |
| Income tax expense | -0.42M | -0.76M | -0.60M | -0.94M | 7.65M |
| Total revenue | 11.51M | 11.69M | 9.76M | 11.96M | 4.33M |
| Total operating expenses | 52.84M | 40.56M | 42.02M | 44.35M | 41.08M |
| Cost of revenue | 3.77M | 1.96M | 2.04M | 2.02M | 2.33M |
| Total other income expense net | -8.89M | -8.42M | -7.61M | -13.98M | -13.53M |
| Net income from continuing ops | -54.00M | -39.25M | -40.82M | -48.40M | -52.60M |
| Net income applicable to common shares | - | - | - | - | -52.59M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 38.32M | 53.42M | 50.76M | 47.45M | 53.27M |
| Intangible assets | 16.02M | 18.48M | 20.12M | 22.44M | 22.65M |
| Other current assets | 9.08M | 12.20M | 10.12M | 7.36M | 4.34M |
| Total liab | 57.01M | 46.93M | 45.87M | 48.81M | 41.41M |
| Total stockholder equity | -17.29M | 7.29M | 4.96M | -0.66M | 11.61M |
| Other current liab | 4.17M | 1.80M | 3.80M | 8.16M | 0.00M |
| Common stock | 0.00M | - | 0.01M | - | 0.01M |
| Capital stock | 2.49M | 0.00M | - | 0.00M | 0.01M |
| Retained earnings | -399.92M | -346.48M | -308.25M | -266.95M | -219.49M |
| Other assets | - | - | 0.00M | - | 0.45M |
| Cash | 0.97M | 8.00M | 6.47M | 5.47M | 17.05M |
| Total current liabilities | 40.65M | 19.70M | 13.99M | 30.34M | 15.47M |
| Current deferred revenue | 0.17M | 0.17M | - | - | 7.12M |
| Net debt | 42.64M | 28.52M | 30.62M | 29.37M | 12.31M |
| Short term debt | 27.63M | 12.34M | 5.21M | 16.37M | 3.42M |
| Short long term debt | 27.44M | 12.04M | - | 15.88M | 3.18M |
| Short long term debt total | 43.61M | 36.53M | 37.09M | 34.84M | 29.36M |
| Other stockholder equity | 380.97M | 354.23M | 313.85M | 266.97M | 231.10M |
| Property plant equipment | - | - | - | - | 1.73M |
| Total current assets | 20.34M | 32.20M | 27.96M | 22.32M | 28.43M |
| Net tangible assets | - | - | - | - | -11.04M |
| Net receivables | 1.70M | 1.65M | 2.18M | 2.47M | 2.14M |
| Long term debt | 15.08M | 23.50M | - | 17.74M | 25.02M |
| Inventory | 8.60M | 10.35M | 9.19M | 7.02M | 4.90M |
| Accounts payable | 8.69M | 5.29M | 4.97M | 5.81M | 4.93M |
| Accumulated other comprehensive income | -0.83M | -0.47M | -0.65M | -0.68M | - |
| Non currrent assets other | 0.49M | 1.35M | 1.01M | 0.99M | 0.45M |
| Non current assets total | 17.98M | 21.23M | 22.80M | 25.13M | 24.83M |
| Capital lease obligations | 1.08M | 0.98M | - | 1.21M | 1.16M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | - | -0.23M | -0.36M | -1.68M | -0.01M |
| Change to liabilities | - | - | - | - | 0.16M |
| Total cashflows from investing activities | 0.15M | -0.23M | 1.23M | - | -0.01M |
| Net borrowings | 13.35M | -0.10M | -0.10M | - | 8.11M |
| Total cash from financing activities | -44.33M | 31.20M | 34.23M | 23.18M | 43.94M |
| Change to operating activities | - | - | - | - | 1.40M |
| Net income | -15.37M | -39.03M | -41.87M | -49.08M | -52.60M |
| Change in cash | -38.35M | 1.53M | 1.00M | -11.58M | 8.96M |
| Begin period cash flow | 46.19M | 6.47M | 5.47M | 17.05M | 8.09M |
| End period cash flow | 7.83M | 8.00M | 6.47M | 5.47M | 17.05M |
| Total cash from operating activities | 5.80M | -29.38M | -33.24M | -33.10M | -34.97M |
| Issuance of capital stock | 10.98M | 31.91M | 24.13M | 20.46M | 33.58M |
| Depreciation | 0.00M | 2.36M | 2.39M | 2.29M | 1.81M |
| Other cashflows from investing activities | 0.17M | -0.21M | - | - | - |
| Change to inventory | 0.90M | -1.16M | -2.17M | -2.12M | -2.12M |
| Change to account receivables | -0.43M | 0.53M | 0.30M | -0.17M | 2.82M |
| Sale purchase of stock | -31.07M | - | - | - | - |
| Other cashflows from financing activities | 5.79M | -0.61M | 2.23M | 2.82M | 12.28M |
| Change to netincome | - | - | - | - | 8.38M |
| Capital expenditures | 0.03M | 0.23M | 0.00M | 1.68M | 0.01M |
| Change in working capital | 12.89M | -3.01M | -11.10M | -4.43M | 2.27M |
| Stock based compensation | -0.81M | 1.64M | 2.11M | 3.32M | 3.97M |
| Other non cash items | 9.09M | 8.66M | 15.23M | 14.79M | 5.19M |
| Free cash flow | 5.77M | -29.61M | -33.24M | -34.78M | -34.98M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| JAGX Jaguar Animal Health Inc |
-0.34 38.56% |
0.54 | - | 200.00 | 0.04 | 0.24 | 0.58 | -0.63 |
| NVO Novo Nordisk A/S |
-0.24 0.61% |
40.20 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
-21.28 3.85% |
531.87 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
12.10 1.26% |
973.36 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Jaguar Health, Inc., a commercial-stage pharmaceuticals company, focuses on developing plant-based prescription medicines for people and animals with gastrointestinal distress. It operates through two segments, Animal Health and Human Health. The company focuses on developing and commercializing prescription and non-prescription products for companion and production animals; and human products. Its lead prescription drug is Mytesi, an anti-secretory antidiarrheal drug for the symptomatic relief of non-infectious diarrhea in adults with HIV/AIDS on antiretroviral therapy; and Canalevia-CA1, a prescription drug product for chemotherapy-induced diarrhea in dogs. It is also developing Crofelemer, an anti-secretory antidiarrheal drug, which is in Phase III clinical trial for prophylaxis of diarrhea in adult cancer patients; Phase II clinical trials for rare/orphan disease indications, including short bowel syndrome with intestinal failure and microvillus inclusion disease; diarrhea-predominant irritable bowel syndrome; and for idiopathic/functional diarrhea. In addition, the company is developing Mytesi which is in Phase III clinical trial for cancer therapy-related diarrhea, as well as Phase II clinical trial for irritable bowel syndrome; and NP-300, a second-generation antidiarrheal drug that is in Phase I clinical trial for symptomatic relief and treatment of moderate-to-severe diarrhea. The company is headquartered in San Francisco, California.
| Name | Title | Year Born |
|---|---|---|
| Ms. Lisa A. Conte | Founder, CEO, Pres & Director | 1959 |
| Mr. Jonathan S. Wolin CPA, J.D., M.B.A. | Chief of Staff, Chief Compliance Officer & Gen. Counsel | 1962 |
| Mr. Ian H. Wendt M.B.A. | Chief Commercial Officer | 1968 |
| Dr. Steven R. King Ph.D. | Chief of Sustainable Supply, Ethnobotanical Research & Intellectual Property and Sec. | 1958 |
| Ms. Carol R. Lizak | Chief Financial Officer | 1964 |
| Dr. Pravin R. Chaturvedi Ph.D. | Chief Scientific Officer & Chair of Scientific Advisory Board | 1963 |
| Mr. Peter Hodge | Sr. Director of Investor Relations, Bus. Devel. & Special Events | NA |
| Dr. Karen J. Brunke Ph.D. | Exec. VP of Corp. & Bus. Devel. | 1952 |
| Mr. David Sesin | Chief Manufacturing Officer | NA |
| Dr. Michael K. Guy D.V.M., M.S., Ph.D. | VP of Preclinical & Nonclinical Studies | NA |
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