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Arvinas, Inc., a clinical-stage biotechnology company, engages in the discovery, development, and commercialization of therapies to degrade disease-causing proteins. The company develops proteolysis targeting chimeras (PROTAC) targeted protein degraders that are designed to harness the body's own natural protein disposal system to degrade and remove disease-causing proteins. It is also developing clinical development programs , including ARV-102, a leucine-rich repeat kinase 2 (LRRK2) protein for the treatment of neurodegenerative diseases, such as Parkinson's disease and progressive supranuclear palsy; ARV-806, a Kirsten rat sarcoma, G12D protein for the treatment of cancers with the G12D mutation, comprising pancreatic, colorectal, and non-small cell lung cancer; ARV-393, a B-cell lymphoma 6 protein for the treatment of relapsed/refractory non-Hodgkin lymphoma (NHL); ARV-027, a polyglutamine-expanded androgen receptor in skeletal muscle; and vepdegestrant, an estrogen receptor for the treatment of locally advanced or metastatic ER+/HER2- breast cancer. In addition, the company develops Bavdegalutamide (ARV-110) and Luxdegalutamide (ARV-766), investigational orally bioavailable PROTAC protein degraders for the treatment of men with metastatic castration-resistant prostate cancer. It has collaborations with Pfizer Inc., Genentech, Inc., F. Hoffman-La Roche Ltd., Carrick Therapeutics Limited, and Bayer AG. The company was founded in 2013 and is based in New Haven, Connecticut.
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Arvinas is a clinical-stage biopharmaceutical company developing targeted protein degraders (PROTACs) to treat oncology and other diseases, with lead candidates such as ARV-471 and ARV-110. Long-term growth may be driven by clinical and regulatory progress, the platform's potential to address traditionally undruggable targets, and potential partnerships or commercial adoption. Investors may find the company attractive for its differentiated technology and pipeline that could produce multiple value inflection points.
Principal risks include clinical and regulatory failure, high cash burn requiring additional financing, and intense competition from other oncology modalities.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -80.50M | -198.30M | -366.40M | -251.00M | -191.00M |
| Net income | -80.80M | -198.90M | -367.30M | -271.90M | -183.20M |
| Selling general administrative | 89.40M | 165.40M | 100.30M | 79.60M | 61.60M |
| Selling and marketing expenses | - | - | 6.70M | - | - |
| Gross profit | 257.40M | 263.40M | 78.50M | 131.40M | 46.70M |
| Reconciled depreciation | 5.20M | 6.60M | 7.10M | 8.20M | 6.00M |
| Ebit | -80.50M | -250.20M | -401.50M | -271.40M | -201.30M |
| Ebitda | -75.30M | -243.60M | -394.80M | -263.20M | -195.30M |
| Depreciation and amortization | 5.20M | 6.60M | 6.70M | 8.20M | 6.00M |
| Non operating income net other | - | - | - | 1.60M | 4.40M |
| Operating income | -114.90M | -250.20M | -401.50M | -263.20M | -195.30M |
| Other operating expenses | 377.50M | 513.60M | 480.00M | 394.60M | 242.00M |
| Interest expense | - | - | - | 12.00M | 0.10M |
| Tax provision | 0.30M | 0.60M | 10.10M | 20.90M | - |
| Interest income | 38.40M | 54.80M | 32.30M | 12.20M | 1.90M |
| Net interest income | 38.40M | 54.80M | 32.30M | 12.20M | 1.80M |
| Income tax expense | 0.30M | 0.60M | 0.90M | 20.90M | -7.80M |
| Total revenue | 262.60M | 263.40M | 78.50M | 131.40M | 46.70M |
| Total operating expenses | 372.30M | 513.60M | 480.00M | 394.60M | 242.00M |
| Cost of revenue | 5.20M | 6.60M | 6.70M | - | - |
| Total other income expense net | 34.40M | 51.90M | 35.10M | 12.20M | 4.30M |
| Net income from continuing ops | -80.80M | -198.90M | -295.40M | -282.50M | -191.00M |
| Net income applicable to common shares | - | - | - | -282.50M | -191.00M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 717.90M | 1091.40M | 1304.60M | 1268.80M | 1581.60M |
| Other current assets | 8.90M | 14.20M | 6.50M | 21.40M | 19.70M |
| Total liab | 284.00M | 529.70M | 644.60M | 703.90M | 799.90M |
| Total stockholder equity | 433.90M | 561.70M | 660.00M | 564.90M | 781.70M |
| Other current liab | 45.30M | 57.20M | 74.40M | 69.00M | 23.10M |
| Common stock | 0.10M | 0.10M | 0.10M | 0.10M | - |
| Capital stock | 0.00M | 0.10M | 0.10M | 0.10M | 0.00M |
| Retained earnings | -1612.40M | -1531.60M | -1332.70M | -965.40M | -682.90M |
| Other liab | - | - | - | 405.10M | 534.30M |
| Other assets | - | - | 0.00M | 10.80M | 0.10M |
| Cash | 142.90M | 100.50M | 317.20M | 81.30M | 108.30M |
| Total current liabilities | 142.50M | 229.80M | 257.10M | 295.10M | 261.70M |
| Current deferred revenue | 71.30M | 156.20M | 163.00M | 218.60M | 206.20M |
| Net debt | -134.40M | -90.80M | -313.80M | -75.80M | -103.30M |
| Short term debt | 1.70M | 1.80M | 2.10M | 1.80M | 1.10M |
| Short long term debt total | 8.50M | 9.70M | 3.40M | 5.50M | 5.00M |
| Other stockholder equity | 2045.00M | 2092.20M | 1995.70M | 1549.40M | 1469.20M |
| Property plant equipment | - | - | - | 13.40M | 16.60M |
| Total current assets | 700.70M | 1067.30M | 1280.20M | 1240.20M | 1552.50M |
| Net tangible assets | - | - | - | 564.90M | 781.70M |
| Short term investments | 542.50M | 938.90M | 949.30M | 1124.00M | 1394.30M |
| Net receivables | 6.40M | 13.70M | 7.20M | 8.00M | 25.70M |
| Long term debt | 0.40M | 0.60M | 0.80M | 1.00M | 1.00M |
| Inventory | - | - | - | 5.50M | 4.50M |
| Accounts payable | 24.20M | 13.20M | 17.60M | 5.70M | 31.30M |
| Accumulated other comprehensive income | 1.20M | 1.00M | -3.10M | -19.20M | -4.60M |
| Common stock total equity | - | - | - | 0.10M | - |
| Retained earnings total equity | - | - | - | -965.40M | -682.90M |
| Non currrent assets other | 3.80M | 8.10M | 10.40M | 10.80M | 12.50M |
| Non current assets total | 17.20M | 24.10M | 24.40M | 28.60M | 29.10M |
| Capital lease obligations | 8.50M | 9.10M | 2.40M | 4.50M | 4.00M |
| Long term debt total | - | - | - | 1.00M | 1.00M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | 409.50M | 34.70M | 276.60M | 249.60M | -1308.90M |
| Change to liabilities | - | - | - | 20.20M | 719.20M |
| Total cashflows from investing activities | 407.60M | 34.70M | 203.50M | 242.80M | -1313.60M |
| Net borrowings | -0.20M | -0.40M | 0.00M | - | - |
| Total cash from financing activities | -91.40M | 7.90M | 374.70M | 4.70M | 278.60M |
| Change to operating activities | - | - | - | - | -26.90M |
| Net income | -80.80M | -198.90M | -367.30M | -282.50M | -191.00M |
| Change in cash | 42.40M | -216.70M | 230.40M | -26.00M | -475.60M |
| Begin period cash flow | 100.50M | 317.20M | 86.80M | 112.80M | 588.40M |
| End period cash flow | 142.90M | 100.50M | 317.20M | 86.80M | 112.80M |
| Total cash from operating activities | -273.80M | -259.30M | -347.80M | -273.50M | 559.40M |
| Issuance of capital stock | 0.00M | 0.00M | 37.10M | 0.00M | 264.60M |
| Depreciation | 5.20M | 6.60M | 6.70M | 8.20M | 6.00M |
| Other cashflows from investing activities | - | 0.10M | - | - | - |
| Change to inventory | - | - | - | - | -26.90M |
| Change to account receivables | 7.30M | -5.70M | 0.80M | 14.00M | -14.00M |
| Sale purchase of stock | -91.90M | 0.00M | 0.00M | 4.70M | 14.00M |
| Other cashflows from financing activities | -91.40M | 8.30M | -12.50M | 242.80M | 14.00M |
| Change to netincome | - | - | - | 75.50M | 65.70M |
| Capital expenditures | 1.90M | 1.80M | 2.90M | 6.80M | 4.70M |
| Change receivables | - | - | - | 17.70M | -17.30M |
| Cash flows other operating | - | - | - | -116.40M | 668.30M |
| Cash and cash equivalents changes | - | - | - | -26.00M | -475.60M |
| Change in working capital | -233.70M | -140.60M | -44.40M | -82.60M | 678.30M |
| Stock based compensation | 44.00M | 88.20M | 71.60M | 75.50M | 57.10M |
| Other non cash items | -8.50M | -14.60M | -14.40M | 7.90M | 9.80M |
| Free cash flow | -275.70M | -261.10M | -350.70M | -280.30M | 554.70M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| ARVN Arvinas Inc |
0.01 0.15% |
6.77 | - | 17.86 | 2.60 | 1.59 | 0.06 | -1.62 |
| NVO Novo Nordisk A/S |
-0.79 1.90% |
40.59 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
-0.79 0.14% |
550.08 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
-6.17 0.67% |
913.79 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Arvinas, Inc., a clinical-stage biotechnology company, engages in the discovery, development, and commercialization of therapies to degrade disease-causing proteins. The company develops proteolysis targeting chimeras (PROTAC) targeted protein degraders that are designed to harness the body's own natural protein disposal system to degrade and remove disease-causing proteins. It is also developing clinical development programs , including ARV-102, a leucine-rich repeat kinase 2 (LRRK2) protein for the treatment of neurodegenerative diseases, such as Parkinson's disease and progressive supranuclear palsy; ARV-806, a Kirsten rat sarcoma, G12D protein for the treatment of cancers with the G12D mutation, comprising pancreatic, colorectal, and non-small cell lung cancer; ARV-393, a B-cell lymphoma 6 protein for the treatment of relapsed/refractory non-Hodgkin lymphoma (NHL); ARV-027, a polyglutamine-expanded androgen receptor in skeletal muscle; and vepdegestrant, an estrogen receptor for the treatment of locally advanced or metastatic ER+/HER2- breast cancer. In addition, the company develops Bavdegalutamide (ARV-110) and Luxdegalutamide (ARV-766), investigational orally bioavailable PROTAC protein degraders for the treatment of men with metastatic castration-resistant prostate cancer. It has collaborations with Pfizer Inc., Genentech, Inc., F. Hoffman-La Roche Ltd., Carrick Therapeutics Limited, and Bayer AG. The company was founded in 2013 and is based in New Haven, Connecticut.
| Name | Title | Year Born |
|---|---|---|
| Dr. John G. Houston Ph.D. | CEO, Pres & Director | 1960 |
| Mr. Sean A. Cassidy CPA, CPA, M.B.A. | CFO & Treasurer | 1970 |
| Dr. Ian Taylor Ph.D. | Chief Scientific Officer | 1962 |
| Dr. Ronald A. Peck | Chief Medical Officer | NA |
| Mr. Jeff Boyle | VP of Investor Relations | NA |
| Mr. Matthew Batters J.D. | Gen. Counsel & Corp. Sec. | 1975 |
| Dr. Randy Teel Ph.D. | Sr. VP of Corp. & Bus. Devel. | 1979 |
| Mr. Steve Weiss | Sr. VP & Chief HR Officer | 1970 |
| Dr. John A. Grosso Ph.D. | Sr. VP of R&D Technical Operations | 1957 |
| Ms. Angela M. Cacace Ph.D. | Sr. VP of Neuroscience & Platform Biology | 1968 |
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