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GT Biopharma, Inc., a clinical stage biopharmaceutical company, engages in the development and commercialization of immuno-oncology products based on its Tri-specific Killer Engager (TriKE) and Tetra-specific Killer Engager (Dual Targeting TriKE) platforms. It develops GTB-3650, which is in phase 1 trials that target CD33 on the surface of myeloid leukemias and an agonistic camelid; GTB-5550, that is in phase 1 dose escalation basket trial that targets B7-H3 on the surface of advanced solid tumors;and GTB-7550, a pre-clinical stage product candidate in development for the treatment of lupus and other autoimmune disorders. The company was formerly known as OXIS International, Inc. and changed its name to GT Biopharma, Inc. in July 2017. GT Biopharma, Inc. was incorporated in 1965 and is based in San Francisco, California.
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GT Biopharma is a clinical-stage biotechnology company developing NK-cell engager immunotherapies based on its TriKE platform for hematologic malignancies. Major long-term growth drivers include advancement of its pipeline in clinical studies, licensing or partnerships, and broader adoption of NK-cell approaches; investors may find the platform's targeted mechanism and potential to support multiple programs attractive.
The most important investment risks are its early-stage status, lack of profitability with significant cash burn requiring additional financing, high clinical and regulatory risk, manufacturing scale-up challenges, and intense competition from larger biopharma firms.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -28.35M | -13.16M | -7.60M | -20.88M | -58.01M |
| Net income | -28.35M | -13.16M | -7.60M | -20.50M | -58.69M |
| Selling general administrative | 8.95M | 8.57M | 8.23M | 12.45M | 47.92M |
| Ebit | - | -27.53M | -7.60M | -21.26M | -57.52M |
| Ebitda | -34.32M | -13.16M | 5.98M | -20.96M | -57.48M |
| Depreciation and amortization | - | 14.36M | 13.58M | 0.29M | 0.04M |
| Operating income | -12.42M | -14.36M | -13.58M | -21.26M | -57.52M |
| Other operating expenses | 12.42M | 14.36M | 13.58M | 21.26M | 57.52M |
| Interest expense | 0.13M | 0.00M | 0.21M | 0.01M | 0.72M |
| Interest income | 0.12M | 0.40M | 0.74M | 0.29M | 0.04M |
| Net interest income | -0.00M | 0.40M | 0.52M | 0.28M | -0.68M |
| Income tax expense | - | - | -0.01M | -0.38M | 0.68M |
| Total revenue | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 12.42M | 14.36M | 13.58M | 21.26M | 57.52M |
| Total other income expense net | -15.93M | 1.20M | 5.98M | 0.37M | -0.50M |
| Net income from continuing ops | -28.35M | -13.16M | -10.22M | -20.88M | -58.01M |
| Net income applicable to common shares | - | - | - | - | -58.01M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 8.11M | 4.23M | 14.11M | 16.74M | 32.17M |
| Other current assets | 1.29M | 0.28M | 0.08M | 0.05M | 0.19M |
| Total liab | 2.32M | 5.90M | 6.63M | 5.00M | 10.26M |
| Total stockholder equity | 5.79M | -1.67M | 7.48M | 11.73M | 21.91M |
| Other current liab | 1.57M | 2.05M | 2.25M | 1.69M | 0.14M |
| Common stock | 0.03M | 0.00M | 0.00M | 0.03M | 1.15M |
| Capital stock | 0.03M | 0.00M | 0.00M | 0.03M | 1.15M |
| Retained earnings | -723.90M | -695.23M | -682.07M | -674.47M | -653.58M |
| Cash | 6.81M | 3.95M | 1.08M | 5.67M | 8.97M |
| Total current liabilities | 2.32M | 5.90M | 6.63M | 4.94M | 10.26M |
| Current deferred revenue | - | - | - | - | 1.90M |
| Net debt | -6.81M | -3.95M | -1.02M | -5.50M | -8.94M |
| Short term debt | - | - | 0.06M | 0.11M | 0.03M |
| Short long term debt | - | - | - | - | 0.03M |
| Short long term debt total | - | - | 0.06M | 0.17M | 0.03M |
| Other stockholder equity | 729.66M | 693.55M | 689.54M | 686.17M | 674.35M |
| Total current assets | 8.11M | 4.23M | 14.06M | 16.56M | 32.17M |
| Net tangible assets | - | - | - | - | 21.91M |
| Short term investments | - | 0.00M | 12.89M | 10.84M | 23.01M |
| Accounts payable | 0.75M | 3.85M | 4.33M | 3.14M | 8.19M |
| Accumulated other comprehensive income | - | - | -0.00M | - | - |
| Non currrent assets other | - | - | - | 0.01M | - |
| Non current assets total | 0.00M | 0.00M | 0.05M | 0.17M | 0.00M |
| Capital lease obligations | - | 0.00M | 0.06M | 0.17M | - |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | 0.00M | 12.89M | 5.02M | 12.14M | -23.04M |
| Change to liabilities | - | - | - | - | 7.08M |
| Total cashflows from investing activities | - | 12.89M | - | - | -23.04M |
| Net borrowings | - | - | - | - | 1.21M |
| Total cash from financing activities | 15.78M | 2.98M | 6.27M | -0.22M | 42.32M |
| Change to operating activities | - | - | - | - | 0.86M |
| Net income | -28.35M | -13.16M | -7.60M | -20.88M | -58.01M |
| Change in cash | 2.86M | 2.96M | -4.59M | -3.30M | 3.67M |
| Begin period cash flow | 4.04M | 1.08M | 5.67M | 8.97M | 5.30M |
| End period cash flow | 6.91M | 4.04M | 1.08M | 5.67M | 8.97M |
| Total cash from operating activities | -12.91M | -12.90M | -8.85M | -15.22M | -15.61M |
| Issuance of capital stock | 10.51M | 2.98M | 6.27M | 6.27M | 24.68M |
| Other cashflows from investing activities | - | 12.89M | - | - | - |
| Dividends paid | 0.23M | 0.00M | - | - | - |
| Sale purchase of stock | - | - | -0.00M | -0.22M | 0.00M |
| Other cashflows from financing activities | 16.00M | 2.98M | -2.01M | -0.04M | 42.32M |
| Change to netincome | - | - | - | - | 34.47M |
| Capital expenditures | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Change in working capital | -0.92M | 0.83M | 1.82M | -1.99M | 7.94M |
| Stock based compensation | 0.43M | 0.23M | 2.20M | 7.65M | 33.93M |
| Other non cash items | 15.93M | -0.80M | -5.28M | 0.01M | 0.54M |
| Free cash flow | -12.91M | -12.90M | -8.85M | -15.22M | -15.61M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| GTBP GT Biopharma Inc |
-0.02 0.51% |
3.94 | - | 17.33 | 204.96 | 2.02 | 773.27 | -0.09 |
| NVO Novo Nordisk A/S |
0.41 1.00% |
41.10 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
-0.86 0.16% |
547.03 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
43.35 4.73% |
959.41 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
GT Biopharma, Inc., a clinical stage biopharmaceutical company, engages in the development and commercialization of immuno-oncology products based on its Tri-specific Killer Engager (TriKE) and Tetra-specific Killer Engager (Dual Targeting TriKE) platforms. It develops GTB-3650, which is in phase 1 trials that target CD33 on the surface of myeloid leukemias and an agonistic camelid; GTB-5550, that is in phase 1 dose escalation basket trial that targets B7-H3 on the surface of advanced solid tumors;and GTB-7550, a pre-clinical stage product candidate in development for the treatment of lupus and other autoimmune disorders. The company was formerly known as OXIS International, Inc. and changed its name to GT Biopharma, Inc. in July 2017. GT Biopharma, Inc. was incorporated in 1965 and is based in San Francisco, California.
315 Montgomery Street, San Francisco, CA, United States, 94104
415 919 4040
1
| Name | Title | Year Born |
|---|---|---|
| Mr. Michael Martin Breen | Interim CEO & Exec. Chairman | 1963 |
| Dr. Gregory I. Berk M.D. | Pres of R&D, Chief Medical Officer and Member of Scientific Advisor Board | 1958 |
| Dr. Gavin S. Choy MBA, PharmD | Chief Clinical Devel. Officer | NA |
| Mr. Manu Ohri | Chief Financial Officer | 1955 |
| Dr. Jeffrey S. Miller M.D. | Consulting Chief Scientific Officer & Scientific Advisor | NA |
| Ms. Stacy Herb M.B.A., M.P.H. | Sr. VP of Portfolio Management | NA |
| Mr. Michael Martin Breen | Interim CEO & Executive Chairman | 1963 |
| Mr. Manu Ohri | CFO & Secretary | 1955 |
| Dr. Jeffrey S. Miller M.D. | Consulting Chief Scientific Officer, Consulting Chief Medical Officer & Scientific Advisor | NA |
| Mr. Michael Martin Breen L.L.B. | President, CEO & Executive Chairman | 1963 |
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