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Kyntra Bio, Inc., a biopharmaceutical company, discovers, develops, and commercializes therapeutics to treat serious unmet medical needs. The company is developing FG-3246, a potential antibody-drug conjugate targeting CD46, for the treatment of metastatic castration-resistant prostate cancer and other cancers. It is also developing Roxadustat, a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase activity, which has completed Phase III clinical development for the treatment of anemia in chronic kidney disease in the United States, Europe, Japan, and other countries, as well as in Phase III clinical development for anemia related with myelodysplastic syndromes. The company has collaboration agreements with Astellas Pharma Inc. and AstraZeneca AB. The company was formerly known as FibroGen, Inc. and change its name to Kyntra Bio, Inc. in January 2026. Kyntra Bio, Inc. was incorporated in 1993 and is headquartered in San Francisco, California.
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Kyntra Bio, Inc. is a NASDAQ-listed company; public filings provide limited detail on its operations and product portfolio. Available disclosure indicates it operates in the biotechnology sector and long-term growth may depend on clinical development progress, regulatory approvals, and strategic partnerships. Investors may find exposure to potential upside from successful R&D and pipeline advancement, but outcomes hinge on execution.
Investors should monitor limited disclosure, clinical and regulatory risk, the likely need for additional financing and dilution, and sector volatility as the primary material risks.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -58.29M | -153.37M | -323.22M | -293.30M | -289.68M |
| Net income | 183.45M | -47.58M | -284.23M | -293.65M | -290.02M |
| Selling general administrative | 27.71M | 49.33M | 86.48M | 124.69M | 123.92M |
| Gross profit | 5.88M | 14.06M | 42.84M | 120.45M | -213.88M |
| Reconciled depreciation | 0.75M | 2.69M | 9.93M | 10.60M | 14.81M |
| Ebit | -58.29M | -145.12M | -315.13M | -293.43M | -348.53M |
| Ebitda | -57.55M | -142.43M | -305.20M | -282.82M | -333.72M |
| Depreciation and amortization | 0.75M | 2.69M | 9.93M | 10.60M | 14.81M |
| Operating income | -45.90M | -150.42M | -322.72M | -301.02M | -288.53M |
| Other operating expenses | 52.34M | 180.04M | 369.52M | 441.76M | 523.84M |
| Interest expense | 8.76M | 8.25M | 8.10M | 1.44M | 1.07M |
| Tax provision | -0.09M | -0.27M | -0.25M | 0.36M | 0.35M |
| Interest income | 2.94M | 5.30M | 7.59M | 7.60M | - |
| Net interest income | -5.82M | -2.95M | -0.50M | 6.16M | -2.15M |
| Income tax expense | -0.09M | -0.27M | -0.25M | 0.36M | 0.35M |
| Total revenue | 6.44M | 29.62M | 46.80M | 140.73M | 235.31M |
| Total operating expenses | 51.78M | 164.48M | 365.56M | 421.48M | 74.65M |
| Cost of revenue | 0.56M | 15.56M | 3.96M | 20.28M | 449.19M |
| Total other income expense net | -12.40M | -2.95M | -0.50M | 7.73M | -1.15M |
| Net income from continuing ops | -58.20M | -153.10M | -322.97M | -293.65M | -290.02M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 119.59M | 214.53M | 423.53M | 610.09M | 773.82M |
| Other current assets | 2.14M | 113.89M | 13.36M | 14.08M | 12.45M |
| Total liab | 115.12M | 398.16M | 585.73M | 611.57M | 544.71M |
| Total stockholder equity | -30.04M | -225.60M | -204.17M | -21.45M | 209.15M |
| Other current liab | 20.18M | 100.95M | 166.24M | 212.08M | 156.81M |
| Common stock | 1.01M | 1.01M | 0.99M | 0.94M | 0.93M |
| Capital stock | 1.01M | 1.01M | 0.99M | 0.94M | 0.93M |
| Retained earnings | -1706.05M | -1889.50M | -1841.92M | -1557.69M | -1264.03M |
| Cash | 47.87M | 50.48M | 113.69M | 155.70M | 171.22M |
| Total current liabilities | 29.24M | 133.31M | 217.67M | 273.56M | 225.50M |
| Current deferred revenue | 5.31M | 27.29M | 12.74M | 12.74M | 19.03M |
| Net debt | -47.87M | 22.61M | 56.77M | -65.81M | -71.50M |
| Short term debt | - | 0.03M | 14.12M | 10.29M | 10.94M |
| Short long term debt total | 85.54M | 73.09M | 170.46M | 89.89M | 99.72M |
| Other stockholder equity | 1677.18M | 1668.62M | 1643.64M | 1541.02M | 1476.41M |
| Total current assets | 99.07M | 196.51M | 331.56M | 492.83M | 474.06M |
| Long term investments | 20.16M | 0.00M | 5.29M | 9.41M | 171.62M |
| Short term investments | 41.11M | 0.00M | 121.90M | 266.31M | 233.97M |
| Net receivables | 4.22M | 28.98M | 41.05M | 16.30M | 25.40M |
| Long term debt | - | 73.09M | 71.93M | - | - |
| Inventory | 3.74M | 3.15M | 41.56M | 40.44M | 31.02M |
| Accounts payable | 3.75M | 5.06M | 17.96M | 30.76M | 26.10M |
| Accumulated other comprehensive income | -2.18M | -5.73M | -6.88M | -5.72M | -4.16M |
| Non currrent assets other | 0.36M | 18.02M | 5.31M | 7.35M | 8.75M |
| Non current assets total | 20.52M | 18.02M | 91.97M | 117.26M | 299.76M |
| Capital lease obligations | - | 0.00M | 77.68M | 89.89M | 99.72M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | -61.16M | 125.21M | 155.52M | 127.85M | -396.79M |
| Total cashflows from investing activities | 35.42M | 125.99M | 153.66M | 89.12M | -426.97M |
| Net borrowings | -75.01M | -0.04M | 73.59M | -0.54M | -5.89M |
| Total cash from financing activities | -86.03M | -0.26M | 122.75M | 46.78M | -0.56M |
| Net income | 183.45M | -47.58M | -284.23M | -293.65M | -290.02M |
| Change in cash | -54.31M | -11.51M | -42.01M | -15.52M | -507.17M |
| Begin period cash flow | 102.18M | 113.69M | 155.70M | 171.22M | 678.39M |
| End period cash flow | 47.87M | 102.18M | 113.69M | 155.70M | 171.22M |
| Total cash from operating activities | -4.77M | -138.00M | -315.02M | -145.93M | -82.23M |
| Issuance of capital stock | - | 0.00M | 48.41M | 0.00M | 0.00M |
| Depreciation | 0.75M | 2.69M | 9.93M | 10.60M | 14.81M |
| Other cashflows from investing activities | 96.61M | - | - | -34.99M | -25.00M |
| Dividends paid | 3.95M | 2.23M | - | - | - |
| Change to inventory | 5.36M | 22.28M | -1.70M | -11.00M | -14.16M |
| Change to account receivables | -2.54M | -6.74M | 3.43M | 0.77M | 25.18M |
| Sale purchase of stock | -0.07M | - | - | - | - |
| Other cashflows from financing activities | -5.40M | 1.88M | 0.75M | 43.13M | -7.37M |
| Capital expenditures | 0.04M | 0.27M | 2.52M | 38.74M | 30.19M |
| Change in working capital | -153.03M | -117.46M | -119.69M | 70.43M | 60.08M |
| Stock based compensation | 6.58M | 25.21M | 50.77M | 65.60M | 71.16M |
| Other non cash items | -42.52M | -0.87M | 28.20M | 1.09M | 61.74M |
| Free cash flow | -4.81M | -138.26M | -317.54M | -184.67M | -112.42M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| KYNB Kyntra Bio, Inc. |
0.19 5.01% |
3.92 | - | 61.35 | 6.82 | 80.40 | 17.97 | 44.15 |
| NVO Novo Nordisk A/S |
0.47 1.18% |
40.78 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
0.34 0.06% |
547.43 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
8.76 0.97% |
913.11 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Kyntra Bio, Inc., a biopharmaceutical company, discovers, develops, and commercializes therapeutics to treat serious unmet medical needs. The company is developing FG-3246, a potential antibody-drug conjugate targeting CD46, for the treatment of metastatic castration-resistant prostate cancer and other cancers. It is also developing Roxadustat, a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase activity, which has completed Phase III clinical development for the treatment of anemia in chronic kidney disease in the United States, Europe, Japan, and other countries, as well as in Phase III clinical development for anemia related with myelodysplastic syndromes. The company has collaboration agreements with Astellas Pharma Inc. and AstraZeneca AB. The company was formerly known as FibroGen, Inc. and change its name to Kyntra Bio, Inc. in January 2026. Kyntra Bio, Inc. was incorporated in 1993 and is headquartered in San Francisco, California.
| Name | Title | Year Born |
|---|---|---|
| Mr. Thane Wettig | CEO & Director | 1965 |
| Mr. David DeLucia | Senior VP & CFO | 1989 |
| Mr. John Alden | Corporate Secretary & General Counsel | NA |
| Ms. Michelle Simonetti | Head of People and Culture & Executive Director | NA |
| Dr. Carrie Brownstein M.D. | Chief Medical Officer | 1970 |
| Ms. Gaia Vasiliver-Shamis | Director of IR & Communications - LifeSci Advisors | NA |
| Ms. Carol Gaddum | Vice President of Product Development | NA |
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