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Stoke Therapeutics, Inc., an early-stage biopharmaceutical company, develops medicines to treat the underlying causes of severe genetic diseases in the United States. The company utilizes its proprietary targeted augmentation of nuclear gene output to develop antisense oligonucleotides to selectively restore protein levels. Its lead clinical candidate is STK-002, which is in preclinical stage for the treatment of autosomal dominant optic atrophy. The company also develops STK-001, which is in phase I/II clinical trial to treat Dravet syndrome; and programs focused on multiple targets, including haploinsufficiency diseases of the central nervous system and eye. The company has a license and collaboration agreement with Acadia Pharmaceuticals Inc. for the discovery, development, and commercialization of novel RNA-based medicines for the treatment of severe and rare genetic neurodevelopmental diseases of the central nervous system. The company was formerly known as ASOthera Pharmaceuticals, Inc. and changed its name to Stoke Therapeutics, Inc. in May 2016. Stoke Therapeutics, Inc. was incorporated in 2014 and is headquartered in Bedford, Massachusetts.
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| Breakdown | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 |
| Income before tax | -101.07M | -85.81M | -52.24M | -32.33M | -12.52M |
| Minority interest | - | - | - | - | 0.00M |
| Net income | -93.11M | -84.71M | -50.61M | -28.52M | -12.52M |
| Selling general administrative | 38.92M | 31.90M | 20.85M | 11.91M | 4.41M |
| Gross profit | 12.40M | - | - | - | 0.00M |
| Reconciled depreciation | 1.55M | 0.97M | 0.89M | 0.45M | 0.21M |
| Ebit | -105.90M | -87.04M | -53.93M | -36.13M | -12.78M |
| Ebitda | -104.36M | -86.06M | -53.04M | -35.68M | -12.57M |
| Depreciation and amortization | 1.55M | 0.97M | 0.89M | 0.45M | 0.21M |
| Non operating income net other | 0.17M | 0.14M | 0.80M | - | - |
| Operating income | -104.36M | -86.06M | -53.04M | -35.68M | -12.78M |
| Other operating expenses | 116.76M | 86.06M | 53.04M | 35.68M | 12.78M |
| Interest expense | 3.12M | 0.12M | 0.00M | 0.00M | 0.00M |
| Interest income | - | 0.12M | 0.74M | 3.35M | 0.27M |
| Net interest income | 3.12M | 0.12M | 0.74M | 3.35M | 0.27M |
| Extraordinary items | - | - | - | - | 0.00M |
| Non recurring | - | - | - | - | 0.00M |
| Other items | - | - | - | - | 0.00M |
| Income tax expense | -7.96M | -1.09M | -1.63M | -3.80M | 0.26M |
| Total revenue | 12.40M | 0.00M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 116.76M | 86.06M | 53.04M | 35.68M | 12.78M |
| Cost of revenue | - | - | - | - | 0.00M |
| Total other income expense net | 3.29M | 0.26M | 0.80M | 3.35M | -0.01M |
| Discontinued operations | - | - | - | - | 0.00M |
| Net income from continuing ops | -101.07M | -85.81M | -52.24M | -32.33M | -12.52M |
| Net income applicable to common shares | -101.07M | -85.81M | -52.24M | -32.33M | -12.52M |
| Breakdown | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2023-12-31 | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 |
| Total assets | 228.34M | 256.07M | 238.87M | 297.93M | 228.75M |
| Other current assets | 13.88M | 2.96M | 9.28M | 6.62M | 3.28M |
| Total liab | 68.78M | 71.22M | 21.09M | 11.85M | 4.32M |
| Total stockholder equity | 159.56M | 184.85M | 217.78M | 286.08M | 224.43M |
| Deferred long term liab | - | 36.86M | - | - | - |
| Other current liab | 11.75M | 13.39M | 0.54M | 9.93M | 3.35M |
| Common stock | 0.01M | 0.00M | 0.00M | 0.00M | 0.00M |
| Capital stock | 0.01M | 0.00M | 0.00M | 0.00M | 0.00M |
| Retained earnings | -401.85M | -297.15M | -196.08M | -110.28M | -58.03M |
| Other liab | - | 37.11M | 3.95M | 0.34M | 0.22M |
| Other assets | - | 0.57M | 248.51M | 1.32M | 0.20M |
| Cash | 191.44M | 113.56M | 144.90M | 287.31M | 222.47M |
| Total current liabilities | 30.82M | 31.39M | 17.14M | 11.43M | 4.10M |
| Current deferred revenue | 15.31M | 14.88M | 12.71M | - | - |
| Net debt | -184.61M | -111.20M | -143.39M | -287.31M | -222.47M |
| Short term debt | 2.06M | 2.36M | 1.51M | - | - |
| Short long term debt total | 6.83M | 2.36M | 1.51M | - | - |
| Other stockholder equity | 561.43M | 483.17M | 414.02M | 396.35M | 282.46M |
| Property plant equipment | - | 6.67M | 9.08M | 2.67M | 2.51M |
| Total current assets | 215.34M | 244.07M | 229.22M | 293.93M | 226.03M |
| Net tangible assets | - | 184.85M | 217.78M | 286.08M | 224.43M |
| Short term investments | 9.95M | 116.04M | 74.92M | - | - |
| Net receivables | 0.06M | 0.59M | 0.13M | 0.01M | 0.28M |
| Inventory | - | 10.93M | -74.92M | - | - |
| Accounts payable | 1.70M | 0.77M | 2.38M | 1.50M | 0.75M |
| Accumulated other comprehensive income | -0.02M | -1.18M | -0.17M | - | -0.81M |
| Common stock total equity | - | 0.00M | 0.00M | 0.00M | 0.00M |
| Retained earnings total equity | - | -297.15M | -196.08M | -110.28M | - |
| Non currrent assets other | 0.57M | 0.57M | 0.57M | 0.20M | 0.20M |
| Non current assets total | 13.00M | 12.00M | 9.65M | 4.00M | 2.72M |
| Capital lease obligations | 2.06M | 2.36M | 1.51M | - | - |
| Breakdown | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2022-12-31 | 2021-12-31 | 2020-12-31 | 2019-12-31 | 2018-12-31 |
| Investments | -41.92M | -75.23M | -1.05M | -1.63M | -0.93M |
| Change to liabilities | 48.21M | 2.90M | 5.20M | 0.89M | 1.74M |
| Total cashflows from investing activities | -45.88M | -76.43M | -1.05M | -1.63M | -0.93M |
| Net borrowings | - | - | -0.18M | - | 0.00M |
| Total cash from financing activities | 46.41M | 1.28M | 108.11M | 149.76M | 115.64M |
| Change to operating activities | -5.18M | -2.85M | -2.88M | -2.00M | -0.64M |
| Net income | -101.07M | -85.81M | -52.24M | -32.33M | -12.52M |
| Change in cash | -31.34M | -142.05M | 64.84M | 117.07M | 103.75M |
| Begin period cash flow | 145.46M | 287.51M | 222.68M | 105.60M | 1.85M |
| End period cash flow | 114.12M | 145.46M | 287.51M | 222.68M | 105.60M |
| Total cash from operating activities | -31.87M | -66.91M | -42.22M | -31.05M | -10.96M |
| Issuance of capital stock | 45.34M | 0.00M | 105.40M | 151.91M | 116.02M |
| Depreciation | 1.55M | 0.97M | 0.89M | 0.45M | 0.21M |
| Other cashflows from investing activities | - | - | - | 0.00M | 0.01M |
| Dividends paid | - | - | - | - | 0.00M |
| Change to inventory | - | - | - | - | 0.00M |
| Change to account receivables | - | - | - | - | 0.00M |
| Sale purchase of stock | 1.06M | 1.29M | 108.29M | 152.23M | 116.02M |
| Other cashflows from financing activities | 1.06M | 1.28M | 2.71M | -2.15M | 115.62M |
| Change to netincome | 22.85M | 16.48M | 5.77M | 1.93M | 0.25M |
| Capital expenditures | 3.96M | 1.20M | 1.05M | 1.64M | 0.94M |
| Cash flows other operating | -3.40M | -1.45M | -1.84M | - | - |
| Cash and cash equivalents changes | -31.34M | -142.05M | 64.84M | - | - |
| Change in working capital | 43.02M | 0.05M | 2.33M | -1.10M | 1.09M |
| Stock based compensation | 22.85M | 16.45M | 5.77M | 1.92M | 0.24M |
| Other non cash items | 1.78M | 1.26M | 1.04M | 0.00M | 0.01M |
| Free cash flow | -35.83M | -68.11M | -43.27M | -32.69M | -11.90M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| STOK Stoke Therapeutics Inc |
0.47 1.80% |
26.54 | - | - | 75.43 | 4.15 | 52.72 | -4.12 |
| NVO Novo Nordisk A/S |
0.01 0.02% |
40.31 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
4.59 0.85% |
547.09 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
1.45 0.16% |
904.35 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Stoke Therapeutics, Inc., an early-stage biopharmaceutical company, develops medicines to treat the underlying causes of severe genetic diseases in the United States. The company utilizes its proprietary targeted augmentation of nuclear gene output to develop antisense oligonucleotides to selectively restore protein levels. Its lead clinical candidate is STK-002, which is in preclinical stage for the treatment of autosomal dominant optic atrophy. The company also develops STK-001, which is in phase I/II clinical trial to treat Dravet syndrome; and programs focused on multiple targets, including haploinsufficiency diseases of the central nervous system and eye. The company has a license and collaboration agreement with Acadia Pharmaceuticals Inc. for the discovery, development, and commercialization of novel RNA-based medicines for the treatment of severe and rare genetic neurodevelopmental diseases of the central nervous system. The company was formerly known as ASOthera Pharmaceuticals, Inc. and changed its name to Stoke Therapeutics, Inc. in May 2016. Stoke Therapeutics, Inc. was incorporated in 2014 and is headquartered in Bedford, Massachusetts.
45 Wiggins Avenue, Bedford, MA, United States, 01730
781 430 8200
110
| Name | Title | Year Born |
|---|---|---|
| Dr. Edward M. Kaye M.D., Ph.D. | CEO & Director | 1949 |
| Dr. Adrian R. Krainer Ph.D. | Co-Founder, Independent Director & Member of Scientific Advisory Board | 1959 |
| Mr. Stephen J. Tulipano CPA, CPA, MBA | Chief Financial Officer | 1959 |
| Dr. Barry S. Ticho FACC, M.D., Ph.D. | Chief Medical Officer | 1961 |
| Ms. Isabel Aznarez Ph.D. | Co-Founder & Group VP of Discovery Research | 1973 |
| Dr. Huw M. Nash Ph.D. | COO & Chief Bus. Officer | 1967 |
| Mr. Eric Rojas | Head of Investor Relations | NA |
| Mr. Jonathan Allan J.D. | Gen. Counsel | NA |
| Ms. Dawn Kalmar | Chief Communications Officer | 1978 |
| Ms. Joan Wood | Chief HR Officer | NA |
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