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X4 Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the research, development, and commercialization of novel therapeutics for the treatment of rare diseases of the immune system. It offers XOLREMDI, an orally small-molecule selective antagonist of chemokine receptor CXCR4, which is in phase 3 clinical trial for the treatment of patients with warts, hypogammaglobulinemia, infections, and myelokathexis syndrome. It has a license agreement with Abbisko Therapeutics Co Ltd. to manufacture and distribute XOLREMDI in mainland China, Taiwan, Hong Kong and Macau; Norgine to develop, manufacture, and commercialize mavorixafor in Europe, Australia, and New Zealand; and Genzyme Corporation for CXCR4 receptor to develop and commercialize products containing licensed compounds for all therapeutic, prophylactic and diagnostic uses. The company is headquartered in Boston, Massachusetts.
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A unique technical analysis driven score developed by Kalkine showing momentum in stock prices based on select technical indicators identified.
X4 Pharmaceuticals is a clinical-stage biotech developing oral modulators of the CXCR4 chemokine receptor for rare immunology and oncology indications. Long-term growth may come from positive clinical data, expanded indications, and partnerships that could support commercial opportunities in defined patient populations.
Material risks include clinical and regulatory trial failure, lack of product revenue and consequent financing or dilution risk, and reliance on a small pipeline and partnerships.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -79.16M | -37.14M | -101.09M | -93.84M | -88.68M |
| Net income | -79.20M | -37.45M | -101.17M | -93.87M | -88.70M |
| Selling general administrative | 43.52M | 61.52M | 32.14M | 27.02M | 24.70M |
| Gross profit | 28.86M | 1.76M | -2.00M | - | - |
| Reconciled depreciation | 1.28M | 0.80M | 0.48M | 0.51M | 0.50M |
| Ebit | -70.28M | -28.37M | -95.31M | -87.57M | -85.11M |
| Ebitda | -69.00M | -27.58M | -94.89M | -88.59M | -65.59M |
| Depreciation and amortization | 1.28M | 0.80M | 0.42M | -1.02M | 19.52M |
| Non operating income net other | - | - | - | -2.28M | - |
| Operating income | -86.88M | -36.40M | -107.52M | -87.57M | -85.11M |
| Other operating expenses | 122.00M | 38.96M | 107.52M | 88.08M | 75.35M |
| Interest expense | 8.88M | 8.77M | 5.78M | 3.99M | 3.64M |
| Tax provision | 0.04M | 0.31M | 0.06M | 0.03M | 0.02M |
| Interest income | 4.58M | 5.77M | 3.33M | 0.22M | 0.01M |
| Net interest income | -4.30M | -3.00M | -1.70M | -3.77M | -3.63M |
| Income tax expense | 0.04M | 0.31M | 0.08M | 0.03M | 0.02M |
| Total revenue | 35.11M | 2.56M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 115.74M | 38.16M | 107.52M | 88.08M | 75.35M |
| Cost of revenue | 6.26M | 0.80M | 2.00M | - | - |
| Total other income expense net | 7.72M | -0.74M | 6.43M | -6.27M | -3.57M |
| Net income from continuing ops | -79.20M | -37.45M | -111.14M | -93.87M | -88.70M |
| Net income applicable to common shares | - | - | - | -96.41M | -102.64M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 290.46M | 146.45M | 147.26M | 155.59M | 117.18M |
| Intangible assets | 9.25M | 10.00M | - | - | - |
| Other current assets | 3.53M | 5.59M | 7.05M | 5.81M | 5.34M |
| Total liab | 104.17M | 124.30M | 96.16M | 81.53M | 52.76M |
| Total stockholder equity | 186.29M | 22.15M | 51.10M | 74.05M | 64.41M |
| Deferred long term liab | - | - | - | 23.13M | - |
| Other current liab | 18.60M | 23.00M | 12.82M | 12.03M | 7.87M |
| Common stock | 0.09M | 0.01M | 0.17M | 0.12M | 0.03M |
| Capital stock | 0.09M | 0.17M | 0.17M | 0.12M | 0.03M |
| Retained earnings | -594.55M | -515.36M | -477.90M | -376.74M | -282.87M |
| Other liab | - | - | - | 23.30M | 0.83M |
| Good will | 17.35M | 17.35M | 17.35M | 17.35M | 17.35M |
| Other assets | - | - | 0.00M | 1.23M | 1.72M |
| Cash | 217.05M | 55.70M | 99.47M | 121.72M | 81.79M |
| Total current liabilities | 25.76M | 32.88M | 22.86M | 22.32M | 14.02M |
| Current deferred revenue | 0.46M | - | - | - | - |
| Net debt | -139.76M | 22.39M | -41.19M | -83.30M | -42.00M |
| Short term debt | 0.99M | 1.25M | 1.10M | 2.51M | 1.87M |
| Short long term debt | - | - | - | 1.31M | 0.80M |
| Short long term debt total | 77.28M | 78.09M | 58.28M | 38.42M | 39.78M |
| Other stockholder equity | 780.86M | 537.62M | 528.96M | 450.79M | 347.37M |
| Property plant equipment | - | - | - | 1.10M | 10.22M |
| Total current assets | 261.58M | 112.17M | 122.08M | 128.68M | 87.88M |
| Net tangible assets | - | - | - | 56.70M | 47.06M |
| Short term investments | 35.95M | 46.36M | 15.00M | - | - |
| Net receivables | 0.57M | 1.71M | 0.56M | 1.15M | 0.75M |
| Long term debt | 76.29M | 75.42M | 54.57M | 32.30M | 33.14M |
| Inventory | 4.48M | 2.82M | - | - | -0.75M |
| Accounts payable | 5.70M | 8.62M | 8.95M | 7.78M | 4.28M |
| Accumulated other comprehensive income | -0.11M | -0.12M | -0.12M | -0.12M | -0.12M |
| Common stock total equity | - | - | - | 0.12M | - |
| Retained earnings total equity | - | - | - | -376.74M | - |
| Non currrent assets other | 0.69M | 2.08M | 0.65M | 1.23M | 1.72M |
| Non current assets total | 28.88M | 34.27M | 25.18M | 26.91M | 29.30M |
| Capital lease obligations | 0.99M | 2.66M | 3.71M | 4.80M | 5.85M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | 11.15M | 66.99M | -10.08M | -0.10M | -0.61M |
| Change to liabilities | - | - | - | 7.23M | 1.17M |
| Total cashflows from investing activities | 8.15M | 66.99M | -14.88M | -0.10M | -0.61M |
| Net borrowings | 0.00M | 20.00M | 20.44M | -0.80M | - |
| Total cash from financing activities | 238.63M | 20.29M | 88.52M | 117.23M | 74.25M |
| Change to operating activities | - | - | - | 5.74M | -1.50M |
| Net income | -79.20M | -37.45M | -101.17M | -93.87M | -88.70M |
| Change in cash | 161.38M | -43.77M | -22.78M | 39.92M | 2.41M |
| Begin period cash flow | 56.48M | 100.25M | 123.03M | 83.11M | 80.70M |
| End period cash flow | 217.85M | 56.48M | 100.25M | 123.03M | 83.11M |
| Total cash from operating activities | -85.62M | -130.90M | -96.51M | -77.10M | -70.91M |
| Issuance of capital stock | 238.53M | 0.00M | 122.01M | 122.63M | 75.98M |
| Depreciation | 1.28M | 0.80M | 0.42M | 0.51M | 0.50M |
| Other cashflows from investing activities | -3.00M | 98.00M | - | -0.10M | -0.61M |
| Dividends paid | - | - | - | - | 13.94M |
| Change to inventory | -1.66M | -2.82M | 0.00M | - | - |
| Change to account receivables | 0.50M | -1.07M | -1.37M | - | - |
| Sale purchase of stock | - | - | 0.00M | 0.21M | -2.00M |
| Other cashflows from financing activities | 0.10M | 0.29M | 8.08M | -4.61M | 0.26M |
| Change to netincome | - | - | - | 6.15M | 19.29M |
| Capital expenditures | 3.00M | 7.33M | 0.06M | 0.10M | 0.61M |
| Cash flows other operating | - | - | - | 2.87M | - |
| Cash and cash equivalents changes | - | - | - | 40.02M | - |
| Change in working capital | -2.58M | 2.67M | 0.34M | 5.74M | -1.50M |
| Stock based compensation | 4.30M | 8.20M | 8.69M | 5.20M | 6.18M |
| Other non cash items | -9.42M | -105.13M | -4.79M | 5.32M | 19.29M |
| Free cash flow | -88.62M | -138.23M | -96.57M | -77.20M | -71.52M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| XFOR X4 Pharmaceuticals Inc |
-0.01 0.46% |
3.23 | 2.53 | - | 22.65 | 2.31 | 14.40 | 1.10 |
| NVO Novo Nordisk A/S |
0.41 1.00% |
41.10 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
-0.86 0.16% |
547.03 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
43.35 4.73% |
959.41 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
X4 Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the research, development, and commercialization of novel therapeutics for the treatment of rare diseases of the immune system. It offers XOLREMDI, an orally small-molecule selective antagonist of chemokine receptor CXCR4, which is in phase 3 clinical trial for the treatment of patients with warts, hypogammaglobulinemia, infections, and myelokathexis syndrome. It has a license agreement with Abbisko Therapeutics Co Ltd. to manufacture and distribute XOLREMDI in mainland China, Taiwan, Hong Kong and Macau; Norgine to develop, manufacture, and commercialize mavorixafor in Europe, Australia, and New Zealand; and Genzyme Corporation for CXCR4 receptor to develop and commercialize products containing licensed compounds for all therapeutic, prophylactic and diagnostic uses. The company is headquartered in Boston, Massachusetts.
| Name | Title | Year Born |
|---|---|---|
| Dr. Paula Ragan Ph.D. | Founder, CEO, Pres, Sec. & Director | 1971 |
| Mr. Adam S. Mostafa | CFO, Treasurer & Assistant Sec. | 1980 |
| Dr. Murray W. Stewart M.D. | Interim Chief Medical Officer & Director | 1961 |
| Dr. Richard Peters M.D., Ph.D. | Founder | 1963 |
| Dr. Renato T. Skerlj Ph.D. | Founder | NA |
| Dr. Keith T. Flaherty M.D. | Founder & Member of Corp. Advisory Board | 1971 |
| Dr. Mary DiBiase Ph.D. | Chief Operating Officer | 1961 |
| Dr. Arthur Taveras Ph.D. | Chief Scientific Officer | 1964 |
| Dr. Glenn Schulman M.P.H., Pharm. D., Pharm.D. | VP of Investor Relations & Corp. Communications | NA |
| Dr. Robert David Arbeit | Sr. VP of Clinical Devel. and Translational Research | 1948 |
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