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Eloxx Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops small-molecule product candidates that modulate the ribosome and promote readthrough of premature stop codons caused by nonsense mutations in the United States, Israel, and Australia. The company is developing exaluren, a eukaryotic ribosome-selective glycoside in a Phase 2 trial for the treatment of rare kidney diseases, including Alport syndrome with nonsense mutations, cystic fibrosis with nonsense mutations, and nephropathic cystinosis with nonsense mutations, as well as in a preclinical stage for the treatment of autosomal dominant polycystic kidney disease with nonsense mutations. It has collaboration with Almirall, S.A. to develop and commercialize ZKN-013, an oral ribosome modulating agent for the treatment of rare skin diseases, such as recessive dystrophic epidermolysis bullosa and junctional epidermolysis bullosa with nonsense mutations. Eloxx Pharmaceuticals, Inc. is based in Arlington, Massachusetts.
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Eloxx Pharmaceuticals is a clinical-stage biopharma developing small molecules to promote read-through of premature stop codons in rare genetic diseases caused by nonsense mutations. Growth may be driven by clinical readouts, regulatory approvals, indication expansion, and partnerships. It could appeal to investors by addressing clear unmet needs with biomarker-driven programs.
Principal risks include failure in pivotal trials or regulatory review, limited cash runway and dilution risk, competition from gene therapies and alternative approaches, and recruitment challenges in rare-disease studies.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -6.00M | -3.14M | -17.05M | -36.06M | -66.73M |
| Net income | -6.00M | -3.14M | -17.05M | -36.11M | -65.77M |
| Selling general administrative | 3.38M | 5.25M | 8.69M | 10.69M | 20.45M |
| Reconciled depreciation | 0.00M | 0.16M | 0.81M | 0.69M | 0.96M |
| Ebit | -6.68M | - | - | -35.11M | -66.98M |
| Ebitda | -6.44M | - | - | -34.42M | -66.02M |
| Depreciation and amortization | 0.24M | - | - | 0.69M | 0.96M |
| Operating income | -6.44M | -2.47M | -17.29M | -34.42M | -66.02M |
| Other operating expenses | 6.44M | - | - | 34.42M | 66.02M |
| Interest expense | 1.05M | 1.14M | 1.15M | 1.95M | 1.26M |
| Interest income | 0.03M | 0.03M | 0.25M | 0.27M | 0.01M |
| Net interest income | -0.86M | -1.12M | -0.90M | -1.68M | -1.25M |
| Income tax expense | - | - | - | 0.05M | -0.96M |
| Total revenue | 0.00M | 6.36M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 6.44M | 8.83M | 17.29M | 34.42M | 66.02M |
| Total other income expense net | 0.44M | 0.44M | 1.13M | -1.65M | -0.71M |
| Net income from continuing ops | -6.00M | -3.14M | -17.05M | -36.06M | -66.73M |
| Net income applicable to common shares | - | - | - | - | -66.73M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 5.27M | 2.98M | 1.71M | 21.12M | 45.14M |
| Other current assets | 0.48M | 0.14M | 0.19M | 0.66M | 1.21M |
| Total liab | 17.18M | 27.31M | 24.31M | 31.78M | 22.75M |
| Total stockholder equity | -11.91M | -24.34M | -22.60M | -10.66M | 22.38M |
| Other current liab | 13.46M | 0.10M | 0.47M | 2.84M | 4.20M |
| Common stock | 0.05M | - | - | 0.02M | 0.87M |
| Capital stock | 0.05M | 0.04M | 0.03M | 0.02M | 0.87M |
| Retained earnings | -300.58M | -294.58M | -291.44M | -274.39M | -238.32M |
| Cash | 4.79M | 0.11M | 1.13M | 19.21M | 42.27M |
| Total current liabilities | 17.18M | 27.31M | 22.70M | 23.09M | 9.96M |
| Current deferred revenue | - | - | - | 12.54M | 3.72M |
| Net debt | -3.79M | 6.41M | 2.70M | -5.82M | -28.81M |
| Short term debt | 1.00M | - | - | 4.69M | 0.66M |
| Short long term debt | 1.00M | 6.52M | 2.22M | 3.98M | - |
| Short long term debt total | 1.00M | - | - | 13.38M | 13.46M |
| Other stockholder equity | 288.62M | - | - | 263.71M | 259.84M |
| Property plant equipment | - | - | - | - | 1.66M |
| Total current assets | 5.27M | 2.98M | 1.55M | 20.13M | 43.48M |
| Net tangible assets | - | - | - | -10.66M | 22.38M |
| Net receivables | 0.00M | 2.36M | 0.00M | - | - |
| Long term debt | - | - | 1.61M | 8.56M | 12.00M |
| Accounts payable | 2.71M | 5.35M | 5.70M | 3.02M | 1.38M |
| Non current assets total | 0.00M | 0.00M | 0.16M | 0.99M | 1.66M |
| Capital lease obligations | 0.00M | 0.00M | 0.14M | 0.85M | 1.46M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | - | - | 0.26M | -0.07M | 2.06M |
| Change to liabilities | - | - | - | 0.00M | -0.32M |
| Total cashflows from investing activities | 0.00M | - | - | - | 2.06M |
| Net borrowings | 1.61M | 3.06M | -9.40M | - | 0.49M |
| Total cash from financing activities | 11.00M | 3.44M | -4.08M | 8.81M | 50.79M |
| Change to operating activities | - | - | - | - | -0.71M |
| Net income | -6.00M | -3.14M | -17.05M | -36.06M | -66.73M |
| Change in cash | 4.67M | -1.24M | -18.11M | -23.10M | 17.84M |
| Begin period cash flow | 0.12M | 1.35M | 19.47M | 42.57M | 24.72M |
| End period cash flow | 4.79M | 0.12M | 1.35M | 19.47M | 42.57M |
| Total cash from operating activities | -6.33M | -4.71M | -14.34M | -31.84M | -35.00M |
| Issuance of capital stock | 0.00M | 0.00M | 4.89M | 0.00M | 47.72M |
| Depreciation | 0.24M | 0.16M | 0.81M | 0.69M | 0.96M |
| Other cashflows from investing activities | 0.00M | - | - | - | - |
| Change to account receivables | 2.36M | -2.36M | 0.00M | - | - |
| Other cashflows from financing activities | 9.39M | - | - | 8.81M | 14.45M |
| Change to netincome | - | - | - | - | 31.38M |
| Capital expenditures | 0.00M | 0.00M | 0.00M | 0.07M | 0.09M |
| Change in working capital | 0.52M | -2.36M | 0.84M | -0.12M | -0.03M |
| Stock based compensation | 0.23M | 0.54M | 1.97M | 3.02M | 9.17M |
| Other non cash items | -1.33M | 0.47M | 0.49M | 0.62M | 22.09M |
| Free cash flow | -6.33M | -4.71M | -14.34M | -31.91M | -35.09M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|
| ELOX Eloxx Pharmaceuticals, Inc. |
-0.36 2.81% |
12.44 | - | - | - | 62.37 | 0.10 |
| NVO Novo Nordisk A/S |
0.01 0.02% |
40.31 | 41.58 | 31.15 | 2.13 | 32.99 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
4.59 0.85% |
547.09 | 30.22 | 24.27 | 10.36 | 6.50 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
1.45 0.16% |
904.35 | 29.07 | 20.12 | 7.57 | 3.82 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 36.06 |
Eloxx Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops small-molecule product candidates that modulate the ribosome and promote readthrough of premature stop codons caused by nonsense mutations in the United States, Israel, and Australia. The company is developing exaluren, a eukaryotic ribosome-selective glycoside in a Phase 2 trial for the treatment of rare kidney diseases, including Alport syndrome with nonsense mutations, cystic fibrosis with nonsense mutations, and nephropathic cystinosis with nonsense mutations, as well as in a preclinical stage for the treatment of autosomal dominant polycystic kidney disease with nonsense mutations. It has collaboration with Almirall, S.A. to develop and commercialize ZKN-013, an oral ribosome modulating agent for the treatment of rare skin diseases, such as recessive dystrophic epidermolysis bullosa and junctional epidermolysis bullosa with nonsense mutations. Eloxx Pharmaceuticals, Inc. is based in Arlington, Massachusetts.
| Name | Title | Year Born |
|---|---|---|
| Mr. Sumit Aggarwal M.B.A. | Pres, CEO & Director | 1973 |
| Mr. Daniel E. Geffken M.B.A., MBA | Interim CFO, Principal Financial Officer & Principal Accounting Officer | 1957 |
| Dr. Vijay Modur MBBS, Ph.D. | Head of R&D | 1968 |
| Ms. Barbara Ryan | Investor Relations Officer | NA |
| Dr. Ali Hariri M.D. | Chief Medical Officer | NA |
| Mr. Matthew Goddeeris Ph.D. | VP of Research | NA |
| Mr. Sumit Aggarwal M.B.A. | President, CEO & Director | 1973 |
| Mr. Daniel E. Geffken M.B.A. | Interim CFO, Principal Financial Officer & Principal Accounting Officer | 1957 |
| Ms. Barbara A. Ryan | Investor Relations Officer | 1960 |
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