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Kymera Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing small molecule therapeutics that selectively degrade disease-causing proteins by harnessing the body's own natural protein degradation system. It engages in developing KT-621, an oral STAT6 degrader in Phase 2b clinical trials for moderate to severe atopic dermatitis, asthma, COPD, EoE, CRSwNP, CSU, PN, BP, and others; KT-579, an oral IRF5 degrader in Phase 1 trials for autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, SSc, DM, and others; KT-485/SAR447971, IRAK4 program, which is in Phase II clinical trial for the treatment of immunology-inflammation diseases, including hidradenitis suppurativa and atopic dermatitis; and cyclin-dependent kinase 2 (CDK2) with broad oncology treatment potential, including in breast cancer and other solid tumors. The company has a strategic alliance with Sanofi S.A. for the development of drug candidates targeting IRAK4 outside the oncology and immuno-oncology fields. Kymera Therapeutics, Inc. was incorporated in 2015 and is headquartered in Watertown, Massachusetts.
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Kymera Therapeutics is a clinical-stage biopharmaceutical company developing targeted protein degraders with a proprietary discovery platform to address immune/inflammatory diseases and oncology. Long-term growth drivers include clinical validation of the platform, advancement of lead candidates, and strategic partnerships that may support development and commercialization, offering investors exposure to a modality that could target previously undruggable proteins.
Investors should monitor clinical and regulatory uncertainty for a novel modality, continued need for financing while unprofitable, and competitive and intellectual-property pressures.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -311.62M | -223.86M | -146.96M | -154.81M | -100.22M |
| Net income | -311.40M | -223.86M | -146.96M | -151.83M | -98.00M |
| Selling general administrative | 68.20M | 63.53M | 55.04M | 43.83M | 36.34M |
| Gross profit | 39.20M | 47.07M | 78.59M | 46.83M | 72.83M |
| Reconciled depreciation | 8.31M | 7.37M | 3.56M | 2.98M | 2.40M |
| Ebit | -311.37M | -223.61M | -146.77M | -161.26M | -100.53M |
| Ebitda | -303.06M | -216.24M | -143.20M | -154.63M | -100.04M |
| Depreciation and amortization | 8.31M | 7.37M | 3.56M | 6.62M | 0.49M |
| Non operating income net other | - | - | - | 6.45M | 0.31M |
| Operating income | -349.40M | -261.63M | -165.53M | -161.26M | -100.53M |
| Other operating expenses | 388.60M | 308.71M | 244.12M | 208.08M | 173.36M |
| Interest expense | 0.25M | 0.25M | 0.20M | 0.18M | 0.17M |
| Interest income | 38.42M | 38.03M | 18.76M | 6.62M | 0.49M |
| Net interest income | 38.05M | 37.78M | 18.57M | 6.45M | 0.31M |
| Income tax expense | - | - | 18.76M | -2.98M | -2.22M |
| Total revenue | 39.20M | 47.07M | 78.59M | 46.83M | 72.83M |
| Total operating expenses | 388.60M | 308.71M | 244.12M | 208.08M | 173.36M |
| Cost of revenue | - | 7.37M | 189.08M | - | - |
| Total other income expense net | 37.78M | 37.78M | 18.57M | 6.45M | 0.31M |
| Net income from continuing ops | -311.35M | -223.86M | -146.96M | -154.81M | -100.22M |
| Net income applicable to common shares | - | - | - | -154.81M | -100.22M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 1742.81M | 978.03M | 575.76M | 603.13M | 605.90M |
| Other current assets | 22.94M | 20.58M | 11.67M | 9.71M | 8.86M |
| Total liab | 163.15M | 142.42M | 180.79M | 112.98M | 146.27M |
| Total stockholder equity | 1579.66M | 835.62M | 394.97M | 490.15M | 459.64M |
| Other current liab | 42.52M | 35.09M | 34.39M | -8.28M | -7.60M |
| Common stock | 0.01M | 0.01M | 0.01M | 0.01M | 0.01M |
| Capital stock | 0.01M | 0.01M | 0.01M | 0.01M | 0.01M |
| Retained earnings | -1065.96M | -754.61M | -530.75M | -383.79M | -228.98M |
| Other liab | - | - | - | 28.25M | 39.36M |
| Other assets | - | - | - | 9.15M | 8.14M |
| Cash | 357.01M | 120.26M | 109.97M | 68.39M | 47.98M |
| Total current liabilities | 83.21M | 67.77M | 85.69M | 63.26M | 101.03M |
| Current deferred revenue | 22.93M | 13.58M | 37.88M | 63.26M | 101.03M |
| Net debt | -274.76M | -32.49M | -25.29M | -51.06M | -30.01M |
| Short term debt | 13.76M | 13.11M | 6.34M | 3.94M | 3.60M |
| Short long term debt total | 82.25M | 87.76M | 84.67M | 17.34M | 17.96M |
| Other stockholder equity | 2643.82M | 1591.71M | 926.27M | 878.88M | 689.27M |
| Property plant equipment | - | - | - | 13.33M | 11.88M |
| Total current assets | 871.21M | 510.27M | 405.32M | 559.49M | 567.61M |
| Long term investments | 771.16M | 362.16M | 61.43M | 152.33M | 125.19M |
| Net tangible assets | - | - | - | 490.15M | 459.64M |
| Short term investments | 491.26M | 368.49M | 264.92M | 338.77M | 394.44M |
| Net receivables | - | 0.95M | 18.76M | 2.54M | 0.14M |
| Inventory | - | - | 0.00M | -12.25M | -8.99M |
| Accounts payable | 4.01M | 5.99M | 7.08M | 4.33M | 4.00M |
| Accumulated other comprehensive income | 1.80M | -1.49M | -0.55M | -4.95M | -0.66M |
| Common stock total equity | - | - | - | 0.01M | 0.01M |
| Retained earnings total equity | - | - | - | -383.79M | -228.98M |
| Non currrent assets other | 9.11M | 7.74M | 7.93M | -122.02M | -98.77M |
| Non current assets total | 871.60M | 467.77M | 170.44M | 43.64M | 38.30M |
| Capital lease obligations | 82.25M | 87.76M | 84.67M | 17.34M | 17.96M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | -519.61M | -404.08M | 71.27M | 20.52M | -98.24M |
| Change to liabilities | - | - | - | 5.03M | 12.74M |
| Total cashflows from investing activities | -521.06M | -404.08M | 139.89M | 20.52M | -99.83M |
| Net borrowings | -1.49M | -1.58M | -0.08M | -1.13M | -0.85M |
| Total cash from financing activities | 990.71M | 608.85M | 4.19M | 153.00M | 250.28M |
| Change to operating activities | - | - | - | 2.30M | 6.08M |
| Net income | -311.35M | -223.86M | -146.96M | -154.81M | -100.22M |
| Change in cash | 236.76M | 10.27M | 41.25M | 20.43M | 21.50M |
| Begin period cash flow | 126.05M | 115.78M | 74.53M | 54.09M | 32.59M |
| End period cash flow | 362.81M | 126.05M | 115.78M | 74.53M | 54.09M |
| Total cash from operating activities | -232.89M | -194.50M | -102.83M | -153.09M | -128.95M |
| Issuance of capital stock | 928.90M | 596.62M | 0.00M | 149.82M | 243.11M |
| Depreciation | 8.31M | 7.37M | 3.56M | 2.98M | 2.40M |
| Other cashflows from investing activities | 8.88M | 13.98M | 174.37M | - | - |
| Change to inventory | - | - | 23.37M | - | 8.71M |
| Change to account receivables | 0.95M | 17.82M | -16.23M | -2.40M | 0.58M |
| Sale purchase of stock | - | - | - | 4.30M | 8.02M |
| Other cashflows from financing activities | 990.71M | 13.81M | 4.27M | 4.30M | 8.02M |
| Change to netincome | - | - | - | 35.48M | 24.99M |
| Capital expenditures | 1.45M | 12.84M | 34.48M | 2.84M | 1.60M |
| Change receivables | - | - | - | - | 0.58M |
| Cash flows other operating | - | - | - | -41.76M | -69.43M |
| Cash and cash equivalents changes | - | - | - | 20.43M | 21.50M |
| Change in working capital | 15.27M | -23.97M | 9.25M | -37.62M | -61.92M |
| Stock based compensation | 59.90M | 55.01M | 43.12M | 35.48M | 24.97M |
| Other non cash items | -5.02M | -9.06M | -11.80M | 0.89M | 5.83M |
| Free cash flow | -234.34M | -207.34M | -137.31M | -155.92M | -130.54M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| KYMR Kymera Therapeutics Inc |
7.13 5.41% |
138.86 | - | - | 88.64 | 6.32 | 85.06 | -9.49 |
| NVO Novo Nordisk A/S |
1.09 2.72% |
41.41 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
3.78 0.69% |
550.87 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
15.61 1.73% |
919.96 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Kymera Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on discovering and developing small molecule therapeutics that selectively degrade disease-causing proteins by harnessing the body's own natural protein degradation system. It engages in developing KT-621, an oral STAT6 degrader in Phase 2b clinical trials for moderate to severe atopic dermatitis, asthma, COPD, EoE, CRSwNP, CSU, PN, BP, and others; KT-579, an oral IRF5 degrader in Phase 1 trials for autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, SSc, DM, and others; KT-485/SAR447971, IRAK4 program, which is in Phase II clinical trial for the treatment of immunology-inflammation diseases, including hidradenitis suppurativa and atopic dermatitis; and cyclin-dependent kinase 2 (CDK2) with broad oncology treatment potential, including in breast cancer and other solid tumors. The company has a strategic alliance with Sanofi S.A. for the development of drug candidates targeting IRAK4 outside the oncology and immuno-oncology fields. Kymera Therapeutics, Inc. was incorporated in 2015 and is headquartered in Watertown, Massachusetts.
500 North Beacon Street, Watertown, MA, United States, 02472
857 285 5300
273
| Name | Title | Year Born |
|---|---|---|
| Dr. Bruce L. Booth D.Phil., DPHIL, Ph.D. | Co-Founder & Chairman | 1974 |
| Dr. Nello Mainolfi M.D., Ph.D. | Co-Founder, Pres, CEO & Director | 1979 |
| Mr. Bruce N. Jacobs CFA | Chief Financial Officer | NA |
| Dr. Jared A. Gollob M.D. | Chief Medical Officer | 1965 |
| Ms. Elaine Caughey | Chief Bus. Officer | NA |
| Kevin Dushney | Sr. VP of IT & Operations | NA |
| Mr. Michael J. Todisco | VP of Accounting & Fin. | 1965 |
| Mr. Vijay Sabesan | Sr. VP of Technical Operations | 1972 |
| Ms. Melissa Brody | VP of Bus. Devel. | NA |
| Ms. Karen Weisbach | VP of People & Culture | NA |
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