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Twist Bioscience Corporation engages in the manufacture and sale of synthetic DNA-based products. The company offers synthetic genes and gene fragments used in product development for therapeutics, diagnostics, chemicals/materials, food/agriculture, data storage, and various applications within academic research by biotech, pharma, industrial chemical, and agricultural companies, as well as academic labs; Oligo pools used in targeted NGS, CRISPR gene editing, mutagenesis experiments, DNA origami, DNA computing, data storage in DNA, and other applications; and immunoglobulin G proteins for customers focused on the pursuit of drug discovery and development. It also provides NGS tools comprising library preparation kits, human exome kits, and fixed and custom panels, as well as alliance panels, primarily used within diagnostic tests for various indications, population genetics research and biomarker discovery, translational research, microbiology, and applied markets research; and methylation detection kits for cancer, and rare and inherited disease study, as well as fast hybridization and full RNA sequencing workflow solution. In addition, the company provides synthetic SARS-CoV-2 RNA reference sequences as positive controls for the development of both NGS and reverse transcription-polymerase chain reaction assays; synthetic monkeypox controls; and various respiratory viral controls, including for influenzas, respiratory syncytial virus, rhinoviruses, SARS, MERS, and coronaviruses. Further, it offers SARS-CoV-2 Research Panels, such as the Twist Respiratory Virus Panel and the Pan-Viral Research Panel, for the detection of disease in a research setting; precision DNA libraries used for antibody engineering, affinity maturation, and humanization; and antibody optimization solution to enable simultaneous optimization of multiple characteristics of a given antibody. The company was incorporated in 2013 and is headquartered in South San Francisco, California.
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Twist Bioscience manufactures synthetic DNA on a proprietary silicon-based platform and supplies oligonucleotides and related products to biotech, pharmaceutical, diagnostics and synthetic-biology firms. Long-term growth may be supported by rising demand for gene synthesis in drug discovery, diagnostics and DNA data storage, scale benefits from high-throughput manufacturing and commercial partnerships, making the company a way to gain platform-driven exposure to expanding genomics applications.
Key risks include intense competition, execution and scaling challenges, continued unprofitable operations and capital needs, customer concentration and potential regulatory or technological shifts that could reduce demand.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2023-09-30 | 2022-09-30 | 2021-09-30 | 2020-09-30 | 2019-09-30 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2023-09-30 | 2022-09-30 | 2021-09-30 | 2020-09-30 | 2019-09-30 |
| Income before tax | -203.47M | -228.27M | -154.03M | -139.55M | -107.38M |
| Net income | -204.62M | -217.86M | -152.10M | -139.93M | -107.67M |
| Selling general administrative | 189.74M | 212.95M | 135.90M | 103.27M | 80.13M |
| Gross profit | 89.73M | 84.23M | 51.71M | 28.69M | 6.96M |
| Reconciled depreciation | - | 16.51M | 9.75M | 6.68M | 6.11M |
| Ebit | -217.16M | -249.02M | -153.26M | -117.58M | -108.85M |
| Ebitda | -193.21M | -247.05M | -154.19M | -116.26M | -106.08M |
| Depreciation and amortization | 23.95M | 1.98M | -0.94M | 1.32M | 2.77M |
| Non operating income net other | - | 6.58M | -0.94M | 1.32M | 2.77M |
| Operating income | -217.16M | -249.02M | -153.26M | -117.58M | -108.85M |
| Other operating expenses | 452.01M | 452.59M | 285.59M | 207.68M | 163.24M |
| Interest expense | 0.01M | 0.08M | 0.37M | 0.79M | 1.29M |
| Tax provision | 1.15M | -10.41M | -1.93M | 0.38M | 0.29M |
| Interest income | 14.37M | 3.06M | 0.43M | 1.50M | 3.03M |
| Net interest income | 14.36M | 2.98M | 0.07M | 0.71M | 1.74M |
| Non recurring | - | - | - | 22.50M | - |
| Income tax expense | 1.15M | -10.41M | -1.93M | 0.38M | 0.29M |
| Total revenue | 245.11M | 203.56M | 132.33M | 90.10M | 54.38M |
| Total operating expenses | 296.63M | 333.26M | 204.97M | 146.27M | 115.81M |
| Cost of revenue | 155.38M | 119.33M | 80.62M | 61.41M | 47.43M |
| Total other income expense net | -10.92M | 20.75M | -0.77M | -21.97M | 1.47M |
| Net income from continuing ops | -204.62M | -217.86M | -152.10M | -139.93M | -107.67M |
| Net income applicable to common shares | - | -217.86M | -152.10M | -139.93M | -107.67M |
| Breakdown | 2023-09-30 | 2022-09-30 | 2021-09-30 | 2020-09-30 | 2019-09-30 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2023-09-30 | 2022-09-30 | 2021-09-30 | 2020-09-30 | 2019-09-30 |
| Total assets | 776.40M | 961.38M | 702.10M | 398.88M | 186.99M |
| Intangible assets | 54.48M | 59.74M | 18.26M | 0.31M | 0.51M |
| Other current assets | 11.72M | 11.91M | 8.28M | 6.20M | 2.59M |
| Total liab | 152.97M | 171.99M | 121.28M | 62.62M | 34.91M |
| Total stockholder equity | 623.43M | 789.38M | 580.82M | 336.26M | 152.08M |
| Other current liab | 7.80M | 53.45M | 9.62M | 2.61M | 0.82M |
| Common stock | - | 789.38M | 580.82M | 336.26M | -186.99M |
| Capital stock | - | 0.00M | 0.00M | 0.00M | 0.00M |
| Retained earnings | -1033.03M | -828.42M | -610.55M | -458.45M | -318.52M |
| Other liab | - | 0.06M | 5.07M | 0.35M | 0.16M |
| Good will | 85.81M | 85.81M | 22.43M | 1.14M | 1.14M |
| Other assets | - | -0.00M | 49.90M | 3.40M | 4.38M |
| Cash | 286.47M | 378.69M | 465.83M | 93.67M | 46.73M |
| Total current liabilities | 73.32M | 90.66M | 63.05M | 36.03M | 30.35M |
| Current deferred revenue | 36.57M | 3.48M | 28.76M | 18.85M | 16.44M |
| Net debt | -192.40M | -283.77M | -402.91M | -57.69M | -39.00M |
| Short term debt | 14.90M | 13.64M | 9.77M | 9.74M | 3.33M |
| Short long term debt | - | - | 1.55M | 3.33M | 3.33M |
| Short long term debt total | 94.07M | 94.91M | 62.92M | 35.98M | 7.73M |
| Other stockholder equity | 1657.22M | 1619.64M | 1190.83M | 794.63M | 283.43M |
| Property plant equipment | - | 214.39M | 44.12M | 25.47M | 20.84M |
| Total current assets | 424.26M | 596.48M | 546.50M | 334.87M | 160.13M |
| Net tangible assets | - | 789.38M | 540.12M | 334.82M | 150.44M |
| Short term investments | 49.94M | 126.28M | 12.03M | 196.34M | 91.37M |
| Net receivables | 44.06M | 40.29M | 28.55M | 26.38M | 12.10M |
| Long term debt | - | - | - | 1.40M | 4.40M |
| Inventory | 32.06M | 39.31M | 31.80M | 12.29M | 7.33M |
| Accounts payable | 14.05M | 20.09M | 14.90M | 4.83M | 9.76M |
| Accumulated other comprehensive income | -0.76M | -1.84M | 0.55M | 0.09M | 0.18M |
| Retained earnings total equity | - | -828.42M | -610.55M | -458.45M | -318.52M |
| Non currrent assets other | 8.49M | 4.96M | 9.20M | 3.40M | 4.38M |
| Non current assets total | 352.15M | 364.89M | 155.60M | 64.01M | 26.86M |
| Capital lease obligations | 94.07M | 94.91M | 61.37M | 31.25M | - |
| Long term debt total | - | - | - | 1.40M | 4.40M |
| Breakdown | 2023-09-30 | 2022-09-30 | 2021-09-30 | 2020-09-30 | 2019-09-30 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2023-09-30 | 2022-09-30 | 2021-09-30 | 2020-09-30 | 2019-09-30 |
| Investments | - | -117.16M | 183.70M | -104.78M | -90.07M |
| Change to liabilities | - | 7.38M | 19.02M | -1.71M | 12.30M |
| Total cashflows from investing activities | - | -232.93M | 156.16M | -114.65M | -104.81M |
| Net borrowings | - | -1.56M | -3.33M | -3.33M | -2.50M |
| Total cash from financing activities | 0.91M | 270.53M | 329.18M | 303.73M | 158.58M |
| Change to operating activities | - | 4.42M | 3.77M | -0.44M | 7.71M |
| Net income | -204.62M | -217.86M | -152.10M | -139.93M | -107.67M |
| Change in cash | -90.98M | -87.10M | 373.11M | 46.85M | -34.14M |
| Begin period cash flow | 380.26M | 467.36M | 94.25M | 47.40M | 81.54M |
| End period cash flow | 289.28M | 380.26M | 467.36M | 94.25M | 47.40M |
| Total cash from operating activities | -142.47M | -124.39M | -112.24M | -142.25M | -87.94M |
| Issuance of capital stock | - | 269.82M | 323.86M | 295.56M | 156.21M |
| Depreciation | 29.31M | 16.51M | 9.75M | 6.68M | 6.11M |
| Other cashflows from investing activities | - | -13.91M | -0.48M | - | 0.02M |
| Change to inventory | 7.24M | -7.54M | -19.49M | -4.96M | -1.30M |
| Change to account receivables | -4.32M | -9.62M | -2.20M | -14.27M | -6.68M |
| Sale purchase of stock | -4.41M | -7.75M | -10.85M | -2.42M | 161.08M |
| Other cashflows from financing activities | 5.32M | 10.02M | 19.50M | 13.92M | 4.87M |
| Change to netincome | - | 82.32M | 37.10M | 17.25M | 11.59M |
| Capital expenditures | 27.78M | 101.86M | 27.06M | 9.87M | 14.76M |
| Change receivables | - | -9.62M | -2.20M | -14.27M | -6.68M |
| Cash flows other operating | - | 10.67M | -5.00M | -5.28M | -1.32M |
| Cash and cash equivalents changes | - | -86.78M | 373.09M | 46.83M | -34.17M |
| Change in working capital | 0.41M | -5.36M | -9.38M | -25.18M | 3.00M |
| Stock based compensation | 30.28M | 79.66M | 37.00M | 17.10M | 11.17M |
| Other non cash items | 2.56M | 2.66M | 1.86M | -0.71M | 0.52M |
| Free cash flow | -170.25M | -226.24M | -139.31M | -152.12M | -102.69M |
Sector: Healthcare Industry: Diagnostics & Research
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| TWST Twist Bioscience Corp |
0.18 0.15% |
120.79 | - | - | 6.76 | 3.01 | 5.93 | -9.02 |
| TMO Thermo Fisher Scientific Inc |
17.82 2.63% |
694.76 | 34.71 | 23.87 | 4.62 | 4.43 | 5.29 | 20.89 |
| DHR Danaher Corporation |
3.91 1.73% |
230.25 | 29.09 | 28.01 | 5.67 | 3.20 | 6.00 | 19.09 |
| WUXIF WuXi AppTec Co. Ltd |
- -% |
25.45 | 22.29 | 17.95 | 1.53 | 5.98 | 8.39 | 14.30 |
| WUXAY WuXi AppTec Co. Ltd |
-0.31 1.23% |
24.85 | 23.28 | 18.73 | 1.51 | 6.24 | 8.39 | 14.30 |
Twist Bioscience Corporation engages in the manufacture and sale of synthetic DNA-based products. The company offers synthetic genes and gene fragments used in product development for therapeutics, diagnostics, chemicals/materials, food/agriculture, data storage, and various applications within academic research by biotech, pharma, industrial chemical, and agricultural companies, as well as academic labs; Oligo pools used in targeted NGS, CRISPR gene editing, mutagenesis experiments, DNA origami, DNA computing, data storage in DNA, and other applications; and immunoglobulin G proteins for customers focused on the pursuit of drug discovery and development. It also provides NGS tools comprising library preparation kits, human exome kits, and fixed and custom panels, as well as alliance panels, primarily used within diagnostic tests for various indications, population genetics research and biomarker discovery, translational research, microbiology, and applied markets research; and methylation detection kits for cancer, and rare and inherited disease study, as well as fast hybridization and full RNA sequencing workflow solution. In addition, the company provides synthetic SARS-CoV-2 RNA reference sequences as positive controls for the development of both NGS and reverse transcription-polymerase chain reaction assays; synthetic monkeypox controls; and various respiratory viral controls, including for influenzas, respiratory syncytial virus, rhinoviruses, SARS, MERS, and coronaviruses. Further, it offers SARS-CoV-2 Research Panels, such as the Twist Respiratory Virus Panel and the Pan-Viral Research Panel, for the detection of disease in a research setting; precision DNA libraries used for antibody engineering, affinity maturation, and humanization; and antibody optimization solution to enable simultaneous optimization of multiple characteristics of a given antibody. The company was incorporated in 2013 and is headquartered in South San Francisco, California.
681 Gateway Boulevard, South San Francisco, CA, United States, 94080
800 719 0671
919
| Name | Title | Year Born |
|---|---|---|
| Dr. Emily Marine Leproust Ph.D. | Co-Founder, Chairman & CEO | 1973 |
| Dr. Patrick John Finn Ph.D. | Pres & COO | 1972 |
| Mr. James M. Thorburn | Chief Financial Officer | 1956 |
| Dr. William Charles Banyai Ph.D. | Sr. VP of Advanced Devel., GM of Data Storage & Director | 1955 |
| Mr. Kevin B. Yankton | VP & Chief Accounting Officer | 1967 |
| Mr. Siyuan Chen | Chief Technology Officer | NA |
| Dr. Aaron K. Sato Ph.D. | Chief Scientific Officer | NA |
| Mr. Dennis Cho | Sr. VP, Gen. Counsel, Chief Ethics & Compliance Officer | 1971 |
| Ms. Paula Green | Sr. VP of HR | 1968 |
| Ms. Erin Smith | Sr. VP of Gov. Affairs & Public Policy | NA |
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