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Theriva Biologics, Inc., a clinical-stage company, develops therapeutics to treat cancer and related diseases in areas of high unmet need in the United States. Its lead product candidate, VCN-01 (zabilugene almadenorepvec), a clinical stage oncolytic human adenovirus that is in Phase 1 clinical trials and Phase 2 VIRAGE trial for patients with pancreatic cancer, head and neck squamous cell carcinoma, ovarian cancer, colorectal cancer, and retinoblastoma. The company also develops VCN-11 for treating solid tumors; SYN-004 (ribaxamase), an oral capsule prophylactic therapy that is in Phase 1b/2a clinical trials for the prevention of acute graft-versus-host-disease (aGVHD) in allogeneic hematopoietic cell transplant (HCT); and SYN-020, a recombinant oral formulation of the enzyme intestinal alkaline phosphatase (IAP) for multiple gastrointestinal and metabolic indications. In addition, it develops clinical stage products, such as SYN-006 to prevent aGVH, clostridioides difficile infection, and microbiome damage in patients treated with carbapenem antibiotics; and SYN-007 for preventing antibiotic associated diarrhea with oral ß-lactam antibiotics. The company has a license agreement with Rasayana Therapeutics, Inc. to research, develop, manufacture, and commercialize any product that includes SYN-020, as well as a clinical trial agreement with Washington University School of Medicine in St. Louis to conduct a Phase 1b/2a clinical trial of SYN-004. Theriva Biologics, Inc. is headquartered in Rockville, Maryland.
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Theriva Biologics Inc. is a publicly traded company that identifies as a biologics firm, but public disclosures about its operations and programs are limited. Long-term growth drivers may include advancement of any product candidates, regulatory milestones, strategic collaborations and successful commercialization if applicable, which could support value creation. Investors may find exposure to potential upside in the biotechnology sector attractive despite elevated information risk.
Key investment risks include limited public information, probable early-stage development with significant regulatory and execution uncertainty, funding needs and low trading liquidity that could increase volatility.
Note: The summary and risk score provided above is created by AI and should not be construed as a recommendation of Kalkine.
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Income before tax | -23.74M | -25.65M | -19.99M | -21.11M | -14.27M |
| Minority interest | - | - | - | 0.00M | 0.00M |
| Net income | -25.25M | -25.65M | -18.35M | -19.68M | -14.17M |
| Selling general administrative | 15.45M | 7.40M | 7.16M | 9.86M | 6.47M |
| Selling and marketing expenses | - | - | 0.62M | - | - |
| Gross profit | -0.11M | -0.14M | -0.14M | - | - |
| Reconciled depreciation | 0.11M | 0.14M | 0.12M | 0.09M | 0.09M |
| Ebit | -23.74M | -19.43M | -22.09M | -21.58M | -14.36M |
| Ebitda | -23.63M | -19.29M | -21.96M | -21.45M | -14.27M |
| Depreciation and amortization | 0.11M | 0.14M | 0.14M | 0.13M | 0.09M |
| Operating income | -15.02M | -26.35M | -21.43M | -21.58M | -14.27M |
| Other operating expenses | 15.02M | 26.35M | 21.43M | 21.58M | 14.27M |
| Interest expense | - | - | - | -0.43M | 0.09M |
| Tax provision | 0.00M | 0.00M | -1.77M | -1.43M | - |
| Interest income | 0.29M | 0.70M | 1.44M | 0.51M | 0.01M |
| Net interest income | 0.29M | 0.70M | 1.44M | 0.51M | 0.01M |
| Income tax expense | 1.51M | - | -1.64M | -1.43M | -0.09M |
| Total revenue | 0.00M | 0.00M | 0.00M | 0.00M | 0.00M |
| Total operating expenses | 14.91M | 26.35M | 21.43M | 21.58M | 14.27M |
| Cost of revenue | 0.11M | 0.14M | 0.14M | - | - |
| Total other income expense net | -8.72M | 0.69M | 1.44M | 0.47M | 0.01M |
| Net income from continuing ops | -23.74M | -25.65M | -19.31M | -19.68M | -14.27M |
| Net income applicable to common shares | - | - | - | -19.68M | -23.19M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Total assets | 38.24M | 35.35M | 55.22M | 71.86M | 70.36M |
| Intangible assets | 19.62M | 17.36M | 19.75M | 19.15M | - |
| Other current assets | 0.58M | 1.35M | 2.29M | 3.73M | 1.53M |
| Total liab | 22.86M | 16.29M | 15.52M | 17.30M | 4.96M |
| Total stockholder equity | 15.38M | 19.07M | 39.70M | 54.56M | 65.41M |
| Deferred long term liab | - | - | - | 19.15M | - |
| Other current liab | 8.39M | 6.13M | 5.42M | 5.87M | 2.91M |
| Common stock | 0.03M | 0.00M | 0.02M | 0.02M | 0.13M |
| Capital stock | 0.03M | 0.00M | 2.75M | 2.75M | 0.13M |
| Retained earnings | -358.71M | -334.97M | -309.32M | -290.97M | -271.28M |
| Other liab | - | - | - | 8.83M | - |
| Good will | - | 0.00M | 5.70M | 5.53M | - |
| Other assets | - | - | - | 19.27M | 0.02M |
| Cash | 13.06M | 11.61M | 23.18M | 41.79M | 67.33M |
| Total current liabilities | 10.01M | 7.58M | 6.74M | 7.06M | 3.55M |
| Current deferred revenue | - | - | 2.87M | - | - |
| Net debt | -10.43M | -10.04M | -21.02M | -40.10M | -65.80M |
| Short term debt | 0.61M | 0.60M | 0.55M | 0.27M | 0.12M |
| Short long term debt | 0.06M | 0.06M | 0.06M | 0.06M | - |
| Short long term debt total | 2.63M | 1.56M | 2.15M | 1.68M | 1.53M |
| Other stockholder equity | 373.30M | 355.21M | 346.23M | 343.46M | 336.56M |
| Property plant equipment | - | - | - | 1.54M | 1.48M |
| Total current assets | 17.47M | 16.28M | 27.40M | 45.52M | 68.86M |
| Net tangible assets | - | - | - | 46.30M | 65.41M |
| Net receivables | 3.83M | 3.32M | 1.94M | 0.23M | - |
| Long term debt | 1.67M | 0.09M | 0.16M | 0.22M | - |
| Inventory | - | - | - | -0.23M | - |
| Accounts payable | 1.01M | 0.86M | 0.77M | 0.92M | 0.52M |
| Accumulated other comprehensive income | 0.76M | -1.18M | 0.03M | -0.68M | - |
| Non currrent assets other | 0.08M | 0.17M | 0.08M | 0.12M | 0.02M |
| Non current assets total | 20.77M | 19.07M | 27.82M | 26.34M | 1.51M |
| Capital lease obligations | 0.90M | 1.41M | 1.93M | 1.40M | 1.53M |
| Breakdown | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
|---|---|---|---|---|---|
| Type | yearly | yearly | yearly | yearly | yearly |
| Date | 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 |
| Investments | - | -0.00M | -0.24M | -4.40M | -0.01M |
| Change to liabilities | - | - | - | -0.39M | -0.36M |
| Total cashflows from investing activities | -0.04M | -0.00M | -0.20M | -4.40M | -0.01M |
| Net borrowings | 1.44M | -0.07M | -0.07M | - | - |
| Total cash from financing activities | 18.19M | 5.50M | 0.62M | -1.93M | 74.00M |
| Change to operating activities | - | - | - | -0.24M | 1.24M |
| Net income | -23.74M | -25.65M | -18.35M | -19.68M | -14.27M |
| Change in cash | 1.40M | -11.57M | -18.61M | -25.44M | 61.10M |
| Begin period cash flow | 11.71M | 23.28M | 41.88M | 67.33M | 6.23M |
| End period cash flow | 13.10M | 11.71M | 23.28M | 41.88M | 67.33M |
| Total cash from operating activities | -16.67M | -16.94M | -19.00M | -19.08M | -12.89M |
| Issuance of capital stock | 13.52M | 5.56M | 2.16M | 2.73M | 65.96M |
| Depreciation | 0.11M | 0.14M | 0.14M | 0.09M | 0.09M |
| Sale purchase of stock | - | - | 0.00M | -0.29M | - |
| Other cashflows from financing activities | 3.23M | 5.50M | -1.52M | -2.27M | 8.04M |
| Change to netincome | - | - | - | 1.14M | 0.41M |
| Capital expenditures | 0.04M | 0.00M | 0.20M | 0.12M | 0.01M |
| Change in working capital | -3.06M | 0.73M | 2.31M | -0.81M | 0.88M |
| Stock based compensation | 0.65M | 0.67M | 0.55M | 0.47M | 0.42M |
| Other non cash items | 9.37M | 8.07M | -2.00M | 2.27M | - |
| Free cash flow | -16.70M | -16.94M | -19.20M | -19.20M | -12.90M |
Sector: Healthcare Industry: Biotechnology
|
Stock Name
|
Change
(USD) |
Price
(USD) |
Trailing
PE (x) |
Forward
PE (x) |
Price Sales
TTM (x) |
Price to Book Value (x)
|
Enterprise Value
to Revenue (x) |
Enterprise Value
to EBITDA (x) |
|---|---|---|---|---|---|---|---|---|
| TOVX Theriva Biologics Inc. |
-0.01 4.44% |
0.16 | 0.16 | - | 34.43 | 0.89 | 10.09 | 1.72 |
| NVO Novo Nordisk A/S |
1.03 2.56% |
41.34 | 41.58 | 31.15 | 2.13 | 32.99 | 2.11 | 4.70 |
| VRTX Vertex Pharmaceuticals Inc |
1.49 0.27% |
548.58 | 30.22 | 24.27 | 10.36 | 6.50 | 9.99 | 24.66 |
| REGN Regeneron Pharmaceuticals Inc |
18.16 2.01% |
922.51 | 29.07 | 20.12 | 7.57 | 3.82 | 6.95 | 19.42 |
| ARGNF argenx SE |
- -% |
900.30 | 45.77 | 31.25 | 13.84 | 7.12 | 11.38 | 36.06 |
Theriva Biologics, Inc., a clinical-stage company, develops therapeutics to treat cancer and related diseases in areas of high unmet need in the United States. Its lead product candidate, VCN-01 (zabilugene almadenorepvec), a clinical stage oncolytic human adenovirus that is in Phase 1 clinical trials and Phase 2 VIRAGE trial for patients with pancreatic cancer, head and neck squamous cell carcinoma, ovarian cancer, colorectal cancer, and retinoblastoma. The company also develops VCN-11 for treating solid tumors; SYN-004 (ribaxamase), an oral capsule prophylactic therapy that is in Phase 1b/2a clinical trials for the prevention of acute graft-versus-host-disease (aGVHD) in allogeneic hematopoietic cell transplant (HCT); and SYN-020, a recombinant oral formulation of the enzyme intestinal alkaline phosphatase (IAP) for multiple gastrointestinal and metabolic indications. In addition, it develops clinical stage products, such as SYN-006 to prevent aGVH, clostridioides difficile infection, and microbiome damage in patients treated with carbapenem antibiotics; and SYN-007 for preventing antibiotic associated diarrhea with oral ß-lactam antibiotics. The company has a license agreement with Rasayana Therapeutics, Inc. to research, develop, manufacture, and commercialize any product that includes SYN-020, as well as a clinical trial agreement with Washington University School of Medicine in St. Louis to conduct a Phase 1b/2a clinical trial of SYN-004. Theriva Biologics, Inc. is headquartered in Rockville, Maryland.
9605 Medical Center Drive, Rockville, MD, United States, 20850
301 417 4364
15
| Name | Title | Year Born |
|---|---|---|
| Mr. Steven A. Shallcross CPA | CEO, CFO, Treasurer, Corp. Sec. & Director | 1961 |
| Dr. Frank Tufaro Ph.D. | Chief Operating Officer | 1955 |
| Vincent I. Perrone | Director of Corp. Communication | NA |
| Dr. Vince Wacher Ph.D. | Head of Product and Corp. Devel. | NA |
| Dr. Michael Kaleko M.D., Ph.D. | Sr. VP of R&D | NA |
| Ms. Lara M. Guzman | Sr. Director of Project Operations | NA |
| Mr. Steven A. Shallcross CPA | CEO, CFO, Treasurer, Corporate Secretary & Director | 1961 |
| Dr. Vince Wacher Ph.D. | Senior Vice President of Corporate & Product Development | NA |
| Dr. Ramon Alemany Ph.D. | Senior Vice President of Discovery | NA |
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